The Training Core will provide educational support for all the projects and cores of the Duke University SRC. The focus of the next phase of the Duke SRC is to determine the biological """"""""costs"""""""" of early life toxicant exposures, the biologic mechanisms for developmental impairments and remediation strategies to reduce impacts on humans and ecosystems. This will serve as a unifying theme for activities undertaken by the Training Core. Core components will include continuation of our weekly seminar series and semi-annual focused topic symposia and workshops, and a new initiative to train undergraduate students in research methods of environmental toxicology, chemistry and policy research. The Training Core will recruit and support promising undergraduate students to work in each of the projects and cores, providing direct mentored research experience. Duke has a unique feature: the College of Arts and Sciences, Medical School, Nicholas School of the Environment, and Pratt School of Engineering are not only on the same campus, but are immediately adjacent to each other. This facilitates the integration of diverse approaches to solving environmental problems. A weekly seminar series will feature local and national speakers on the full range of topics relevant to the SRC. These seminars will provide students, postdoctoral fellows, technicians, and faculty with the latest research findings, especially as they relate to biological costs of early life exposures. We will host workshops on state-of-the-art scientific techniques, as well as on scientific communication skills to help us effectively convey our research to scientific colleagues and the broader society. A daylong interdisciplinary symposium will be held on a focused area of environmental pollution to learn, in depth, the ways in which specific pollution problems can be effectively addressed in a collaborative effort. Monthly chalk talks will be held in which all of the projects will in turn discuss their latest results and plans for future studies. Travel and registration funding will be provided for SRC undergraduate, graduate students, and post-doctoral research associates to attend relevant scientific conferences and workshops providing trainees experience in research presentation and promoting the Center itself.

Public Health Relevance

The Training Core provides educational support for all the projects and cores of the Duke University SRC. The Core will interact with all other projects and cores. The emphasis in this renewal application on the potential biological costs of early life exposures and remediation strategies for humans and ecosystems will serve as a unifying theme for the Training Core's seminars, symposia, workshops and chalk talks.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010356-11
Application #
8377315
Study Section
Special Emphasis Panel (ZES1-SET-V)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
11
Fiscal Year
2012
Total Cost
$118,880
Indirect Cost
$60,198
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Mu, Jingli; Chernick, Melissa; Dong, Wu et al. (2017) Early life co-exposures to a real-world PAH mixture and hypoxia result in later life and next generation consequences in medaka (Oryzias latipes). Aquat Toxicol 190:162-173
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Slotkin, Theodore A; Skavicus, Samantha; Seidler, Frederic J (2017) Diazinon and parathion diverge in their effects on development of noradrenergic systems. Brain Res Bull 130:268-273
Lindberg, C D; Jayasundara, N; Kozal, J S et al. (2017) Resistance to polycyclic aromatic hydrocarbon toxicity and associated bioenergetic consequences in a population of Fundulus heteroclitus. Ecotoxicology 26:435-448
Abreu-Villa├ža, Yael; Levin, Edward D (2017) Developmental neurotoxicity of succeeding generations of insecticides. Environ Int 99:55-77
Jayasundara, Nishad; Fernando, Pani W; Osterberg, Joshua S et al. (2017) Cost of Tolerance: Physiological Consequences of Evolved Resistance to Inhabit a Polluted Environment in Teleost Fish Fundulus heteroclitus. Environ Sci Technol 51:8763-8772

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