The Training Core will provide educational support for all the projects and cores of the Duke University SRC. The focus of the next phase of the Duke SRC is to determine the biological "costs" of early life toxicant exposures, the biologic mechanisms for developmental impairments and remediation strategies to reduce impacts on humans and ecosystems. This will serve as a unifying theme for activities undertaken by the Training Core. Core components will include continuation of our weekly seminar series and semi-annual focused topic symposia and workshops, and a new initiative to train undergraduate students in research methods of environmental toxicology, chemistry and policy research. The Training Core will recruit and support promising undergraduate students to work in each of the projects and cores, providing direct mentored research experience. Duke has a unique feature: the College of Arts and Sciences, Medical School, Nicholas School of the Environment, and Pratt School of Engineering are not only on the same campus, but are immediately adjacent to each other. This facilitates the integration of diverse approaches to solving environmental problems. A weekly seminar series will feature local and national speakers on the full range of topics relevant to the SRC. These seminars will provide students, postdoctoral fellows, technicians, and faculty with the latest research findings, especially as they relate to biological costs of early life exposures. We will host workshops on state-of-the-art scientific techniques, as well as on scientific communication skills to help us effectively convey our research to scientific colleagues and the broader society. A daylong interdisciplinary symposium will be held on a focused area of environmental pollution to learn, in depth, the ways in which specific pollution problems can be effectively addressed in a collaborative effort. Monthly chalk talks will be held in which all of the projects will in turn discuss their latest results and plans for future studies. Travel and registration funding will be provided for SRC undergraduate, graduate students, and post-doctoral research associates to attend relevant scientific conferences and workshops providing trainees experience in research presentation and promoting the Center itself.

Public Health Relevance

The Training Core provides educational support for all the projects and cores of the Duke University SRC. The Core will interact with all other projects and cores. The emphasis in this renewal application on the potential biological costs of early life exposures and remediation strategies for humans and ecosystems will serve as a unifying theme for the Training Core's seminars, symposia, workshops and chalk talks.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010356-12
Application #
8450252
Study Section
Special Emphasis Panel (ZES1-SET-V)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
12
Fiscal Year
2013
Total Cost
$112,557
Indirect Cost
$67,508
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Brown, D R; Bailey, J M; Oliveri, A N et al. (2016) Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish. Neurotoxicol Teratol 53:55-63
Luz, Anthony L; Godebo, Tewodros R; Bhatt, Dhaval P et al. (2016) From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans. Toxicol Sci 152:349-62
Lefevre, Emilie; Bossa, Nathan; Wiesner, Mark R et al. (2016) A review of the environmental implications of in situ remediation by nanoscale zero valent iron (nZVI): Behavior, transport and impacts on microbial communities. Sci Total Environ 565:889-901
Czaplicki, L M; Cooper, E; Ferguson, P L et al. (2016) A New Perspective on Sustainable Soil Remediation-Case Study Suggests Novel Fungal Genera Could Facilitate in situ Biodegradation of Hazardous Contaminants. Remediation (N Y) 26:59-72
Chernick, Melissa; Ware, Megan; Albright, Elizabeth et al. (2016) Parental dietary seleno-L-methionine exposure and resultant offspring developmental toxicity. Aquat Toxicol 170:187-98
Cooper, Ellen M; Kroeger, Gretchen; Davis, Katherine et al. (2016) Results from Screening Polyurethane Foam Based Consumer Products for Flame Retardant Chemicals: Assessing Impacts on the Change in the Furniture Flammability Standards. Environ Sci Technol 50:10653-10660
Riley, Amanda K; Chernick, Melissa; Brown, Daniel R et al. (2016) Hepatic Responses of Juvenile Fundulus heteroclitus from Pollution-adapted and Nonadapted Populations Exposed to Elizabeth River Sediment Extract. Toxicol Pathol 44:738-48
Santa-Gonzalez, Gloria A; Gomez-Molina, Andrea; Arcos-Burgos, Mauricio et al. (2016) Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. Redox Biol 9:124-133
Petro, Ann; Sexton, Hannah G; Miranda, Caroline et al. (2016) Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice. BMC Pharmacol Toxicol 17:55
Abreu-Villaça, Yael; Levin, Edward D (2016) Developmental neurotoxicity of succeeding generations of insecticides. Environ Int :

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