The Training Core will provide educational support for all the projects and cores of the Duke University SRC. The focus of the next phase of the Duke SRC is to determine the biological "costs" of early life toxicant exposures, the biologic mechanisms for developmental impairments and remediation strategies to reduce impacts on humans and ecosystems. This will serve as a unifying theme for activities undertaken by the Training Core. Core components will include continuation of our weekly seminar series and semi-annual focused topic symposia and workshops, and a new initiative to train undergraduate students in research methods of environmental toxicology, chemistry and policy research. The Training Core will recruit and support promising undergraduate students to work in each of the projects and cores, providing direct mentored research experience. Duke has a unique feature: the College of Arts and Sciences, Medical School, Nicholas School of the Environment, and Pratt School of Engineering are not only on the same campus, but are immediately adjacent to each other. This facilitates the integration of diverse approaches to solving environmental problems. A weekly seminar series will feature local and national speakers on the full range of topics relevant to the SRC. These seminars will provide students, postdoctoral fellows, technicians, and faculty with the latest research findings, especially as they relate to biological costs of early life exposures. We will host workshops on state-of-the-art scientific techniques, as well as on scientific communication skills to help us effectively convey our research to scientific colleagues and the broader society. A daylong interdisciplinary symposium will be held on a focused area of environmental pollution to learn, in depth, the ways in which specific pollution problems can be effectively addressed in a collaborative effort. Monthly chalk talks will be held in which all of the projects will in turn discuss their latest results and plans for future studies. Travel and registration funding will be provided for SRC undergraduate, graduate students, and post-doctoral research associates to attend relevant scientific conferences and workshops providing trainees experience in research presentation and promoting the Center itself.

Public Health Relevance

The Training Core provides educational support for all the projects and cores of the Duke University SRC. The Core will interact with all other projects and cores. The emphasis in this renewal application on the potential biological costs of early life exposures and remediation strategies for humans and ecosystems will serve as a unifying theme for the Training Core's seminars, symposia, workshops and chalk talks.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Duke University
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Brown, Daniel R; Clark, Bryan W; Garner, Lindsey V T et al. (2015) Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists. Environ Sci Pollut Res Int 22:8329-38
Slotkin, Theodore A; Card, Jennifer; Seidler, Frederic J (2014) Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways. Brain Res Bull 100:44-54
Levin, Edward D; Cauley, Marty; Johnson, Joshua E et al. (2014) Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor. Neurotoxicol Teratol 41:35-42
Pillai, Hari K; Fang, Mingliang; Beglov, Dmitri et al. (2014) Ligand binding and activation of PPAR? by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect 122:1225-32
Bess, Amanda S; Ryde, Ian T; Hinton, David E et al. (2013) UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. J Biochem Mol Toxicol 27:28-41
Dong, Wu; Macaulay, Laura J; Kwok, Kevin W H et al. (2013) Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages. Aquat Toxicol 132-133:190-9
Slotkin, Theodore A; Cooper, Ellen M; Stapleton, Heather M et al. (2013) Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos? Environ Toxicol Pharmacol 36:284-7
Clark, Bryan W; Cooper, Ellen M; Stapleton, Heather M et al. (2013) Compound- and mixture-specific differences in resistance to polycyclic aromatic hydrocarbons and PCB-126 among Fundulus heteroclitus subpopulations throughout the Elizabeth River estuary (Virginia, USA). Environ Sci Technol 47:10556-66
Garner, Lindsey V T; Brown, Daniel R; Di Giulio, Richard T (2013) Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. Aquat Toxicol 142-143:336-46
Zhao, Bin; Bohonowych, Jessica E S; Timme-Laragy, Alicia et al. (2013) Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS One 8:e56860

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