This Superfund Basic Research and Training Program-Reuse in RI: A State-Based Approach to Complex Exposures-tackles through research and outreach three inter-related thematic challenges: 1) land reuse, 2) a state-based approach, and 3) complex exposures. Rhode Island is small, densely populated, and burdened by a long history of industrial activity. There are few barriers to academics, government leaders, and community members working together to address basic and translational research issues, management decisions, and communication complexities inherent to re-using hazardous waste sites. The research clusters 5 Biomedical and 3 Engineering Projects into Interdisciplinary Focus Areas: Nanotechnology &Metals, Molecular Epidemiology &Reproduction, and Semi-Volatile Organics &Vapor Intrusion, that investigate toxicant-induced disease mechanisms and develop potential biomarkers associated with co-exposures, and identify, characterize, separate, and remediate complex mixtures. These projects are supported by an Analytical Core-Chemistry and Biostatistics, a Molecular Pathology Core, and a Training Core. The Research Translation and Community Outreach Cores facilitate the flow of knowledge and information among the participating academics, government leaders, and community members in a true university-state-community partnership. The Administrative Core provides the infrastructure to promote communication, critical self-evaluation, and resource management. This program provides Rhode Islanders with a responsive center of technical excellence that takes a research-oriented approach to resolving the complex scientific, engineering, and societal issues that arise when considering the reuse of hazardous waste sites, by focusing on the following specific objectives: ? Provide Leadership - achieve excellence in basic and applied research, teaching, and service in environmental health and technology. ? Catalyze Research - increase understanding of health risks and solve technological challenges associated with remediation. ? Enhance Connectivity - build bridges across fields and create new interdisciplinary training and educational opportunities. ? Research Translation and Community Outreach - communicate health hazards, guide plans for reuse of contaminated sites, and increase the capacity of state agencies and community groups.

Public Health Relevance

The over-arching goal of this Superfund Basic Research Program is to address health concerns, and to design novel remediation techniques, related to mixed exposures arising from contaminated lands and buildings, using Rhode Island as a model for appropriate research, educational, and training interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES013660-09S1
Application #
8667844
Study Section
Special Emphasis Panel (ZES1-LKB-D (S8))
Program Officer
Henry, Heather F
Project Start
2005-04-18
Project End
2014-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
9
Fiscal Year
2013
Total Cost
$10,800
Indirect Cost
$800
Name
Brown University
Department
Pathology
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Yao, Yijun; Mao, Fang; Ma, Shuaishuai et al. (2017) Three-Dimensional Simulation of Land Drains as a Preferential Pathway for Vapor Intrusion into Buildings. J Environ Qual 46:1424-1433
Kalkunte, Satyan; Huang, Zheping; Lippe, Eliana et al. (2017) Polychlorinated biphenyls target Notch/Dll and VEGF R2 in the mouse placenta and human trophoblast cell lines for their anti-angiogenic effects. Sci Rep 7:39885
Rodd, April L; Messier, Norma J; Vaslet, Charles A et al. (2017) A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures. Aquat Toxicol 186:134-144
Chen, Po-Yen; Liu, Muchun; Wang, Zhongying et al. (2017) From Flatland to Spaceland: Higher Dimensional Patterning with Two-Dimensional Materials. Adv Mater 29:
Yao, Yijun; Verginelli, Iason; Suuberg, Eric M (2017) A two-dimensional analytical model of vapor intrusion involving vertical heterogeneity. Water Resour Res 53:4499-4513
Chen, Po-Yen; Zhang, Mengke; Liu, Muchun et al. (2017) Ultrastretchable Graphene-Based Molecular Barriers for Chemical Protection, Detection, and Actuation. ACS Nano :
Blois, Sandra M; Freitag, Nancy; Tirado-González, Irene et al. (2017) NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface. Sci Rep 7:2189
Thompson, Marcella Remer; Schwartz Barcott, Donna (2017) The concept of exposure in environmental health for nursing. J Adv Nurs 73:1315-1330
Wang, Zhongying; Zhang, Yin-Jia; Liu, Muchun et al. (2017) Oxidation suppression during hydrothermal phase reversion allows synthesis of monolayer semiconducting MoS2 in stable aqueous suspension. Nanoscale 9:5398-5403
Yao, Yijun; Wang, Yue; Zhong, Zhong et al. (2017) Investigating the Role of Soil Texture in Vapor Intrusion from Groundwater Sources. J Environ Qual 46:776-784

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