In this project we assess exposures to atmospheric PCBs among a cohort of children and their mothers in a contaminated area where dredging of PCB-laden sediments will occur during the study period. PCB concentrations are measured through repeated air sampling inside and outside of homes and local schools. Blood samples are collected annually and assayed for PCB congeners. These data are compared to a rural site to characterize high and low exposure residential cohorts. The urban site (East Chicago, IN) has a legacy of PCB contamination from intense past industrial activity whereas the rural site (Columbus Junction, IA) is without local sources of PCBs. The project will continue four original aims and pursue two new aims:
Aim 1. Establish a residential cohort in East Chicago and a rural residential cohort in Columbus Junction;
Aim 2. Measure emissions and exposures of atmospheric PCBs at homes and schools in these communities;
Aim 3. Gather demographic, residential, occupational, activity and dietary information by questionnaire;
Aim 4. Analyze data from these cohorts and develop an exposure model for the atmospheric PCB congeners.
Aim 1 has been achieved but we will to expand the cohort to increase power and span the time before and during the dredging.
Aim 2 and Aim 3 are ongoing. We continue to measure subjects'PCB exposures, collect blood samples and administer questionnaires. We have begun Aim 4 with analysis of survey data and congener-specific PCBs. Two new aims are planned for this renewal.
Aim 5. Measure congener-specific hydroxy metabolites of PCBs in subjects'biobanked extracted and derivitized blood samples.
Aim 6. Adapt a bioaccumulation model to predict the PCB body burden in subjects breathing air with measured PCBs levels and compare modelled data with measured data. Five hypotheses will be tested: H1: East Chicagoans have significantly higher exposures, and (H2) blood levels of atmospheric PCB congeners than rural lowans. H3: Adolescent's burdens of PCB congeners are significantly correlated with those of their mothers. H4: East Chicagoans will experience increased exposures with the dredging of Indiana Harbor and Ship Canals and filling of the Confined Disposal Facility. H5: Bioaccumulation models can predict the relative body burdens of PCBs using measured air data and dietary questionnaire data.

Public Health Relevance

The primary goal of the project is to compare airborne exposures to PCBs between high and low exposure community cohorts and determine the importance of inhalation exposure to the body burden. A second goal is to determine if residential populations living near dredging operations are at increased risk of exposure to atmospheric PCBs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES013661-09
Application #
8659480
Study Section
Special Emphasis Panel (ZES1-LWJ-M)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
9
Fiscal Year
2014
Total Cost
$361,066
Indirect Cost
$120,258
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Herkert, Nicholas J; Spak, Scott N; Smith, Austen et al. (2017) Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environ Sci Process Impacts :
Sethi, Sunjay; Keil, Kimberly P; Chen, Hao et al. (2017) Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons. Toxicol Sci 158:401-411
Kania-Korwel, Izabela; Wu, Xianai; Wang, Kai et al. (2017) Identification of lipidomic markers of chronic 3,3',4,4',5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver. Toxicology 390:124-134
Holland, Erika B; Feng, Wei; Zheng, Jing et al. (2017) An Extended Structure-Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors. Toxicol Sci 155:170-181
Li, Xueshu; Parkin, Sean R; Lehmler, Hans-Joachim (2017) Absolute configuration of 2,2',3,3',6-pentachlorinatedbiphenyl (PCB 84) atropisomers. Environ Sci Pollut Res Int :
Qian, Jiajie; Jennings, Brandon; Cwiertny, David M et al. (2017) Emerging investigator series: development and application of polymeric electrospun nanofiber mats as equilibrium-passive sampler media for organic compounds. Environ Sci Process Impacts 19:1445-1456
Gourronc, Francoise A; Robertson, Larry W; Klingelhutz, Aloysius J (2017) A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environ Sci Pollut Res Int :
Schroer, Hunter W; Langenfeld, Kathryn L; Li, Xueshu et al. (2017) Biotransformation of 2,4-dinitroanisole by a fungal Penicillium sp. Biodegradation 28:95-109
Marek, Rachel F; Thorne, Peter S; Herkert, Nicholas J et al. (2017) Airborne PCBs and OH-PCBs Inside and Outside Urban and Rural U.S. Schools. Environ Sci Technol 51:7853-7860
Dhakal, Kiran; Gadupudi, Gopi S; Lehmler, Hans-Joachim et al. (2017) Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int :

Showing the most recent 10 out of 272 publications