While lead poisoning has been extensively studied, exposure levels remain elevated in many vulnerable populations. Other toxic metals such as arsenic and manganese are also elevated in the environment, but their effects on neurodevelopment are poorly understood. Perhaps more importantly, the effects of mixed metal exposures are pooriy understood, yet this exposure scenario is most reflective of the real worid. In this project we will pool the data and resources from 3 cohort studies of metals and neurodevelopment. One in a developing country-Bangladesh, where metal exposures are unusually high, one in Mexico, a middle income country where metal exposures are moderately high, and one in a developed Country-Tar Creek, OK, where exposures are representative of a community near a US toxic waste site. These cohorts allow us to overcome barriers that prevented research in both metal mixtures and the role of developmental windows in neurotoxicology. Our program will have a final sample size of 2600 children with prospective data on metal exposure, and repeated neurophenotype measures. This will give us sufficient power to model the effects of joint exposures to As/Pb, As/Mn and Mn/Pb and their 3 way interactions on neurodevelopment. In addition, as we have longitudinal exposure data, we can compare the effects of metal exposure during different developmental windows (i.e. pre vs post-natal exposure) on neurodevelopment. This project is also integrated with the nonbiomedial projects. For example, we will partner with projects 4 and 6 to test the effect of deep wells on As/Mn biomarker levels in Bangladesh. We will also partner with Projects 5 and 6 to validate statistical methods for site characterization and the incorporation of bioavailability/metal speciation data into geospatial models of exposure assessment at the Tar Creek Superfund site.
Data on the effects of mixtures of metals on child development will be collected from children starting in prenatal life fill age 2 years. We will also measure whether the timing of exposure determines effects and whether repeated exposure multiplicatively increases toxicity. Finally, we will partner with nonbiomedical projects to determine how ecological factors increase or decrease exposure in impacted communities.
|Rosa-Parra, Jose A; Tamayo-Ortiz, Marcela; Lamadrid-Figueroa, Hector et al. (2018) Diurnal Cortisol Concentrations and Growth Indexes of 12- to 48-Month-Old Children From Mexico City. J Clin Endocrinol Metab 103:3386-3393|
|Lee, Jane J; Valeri, Linda; Kapur, Kush et al. (2018) Growth parameters at birth mediate the relationship between prenatal manganese exposure and cognitive test scores among a cohort of 2- to 3-year-old Bangladeshi children. Int J Epidemiol 47:1169-1179|
|Sun, Ryan; Carroll, Raymond J; Christiani, David C et al. (2018) Testing for gene-environment interaction under exposure misspecification. Biometrics 74:653-662|
|Sun, Ryan; Wang, Zhaoxi; Claus Henn, Birgit et al. (2018) Identification of novel loci associated with infant cognitive ability. Mol Psychiatry :|
|Woo, May K; Young, Elisabeth S; Mostofa, Md Golam et al. (2018) Lead in Air in Bangladesh: Exposure in a Rural Community with Elevated Blood Lead Concentrations among Young Children. Int J Environ Res Public Health 15:|
|von Stackelberg, Katherine; Li, Miling; Sunderland, Elsie (2017) Results of a national survey of high-frequency fish consumers in the United States. Environ Res 158:126-136|
|Valeri, Linda; Mazumdar, Maitreyi M; Bobb, Jennifer F et al. (2017) The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20-40 Months of Age: Evidence from Rural Bangladesh. Environ Health Perspect 125:067015|
|Claus Henn, Birgit; Bellinger, David C; Hopkins, Marianne R et al. (2017) Maternal and Cord Blood Manganese Concentrations and Early Childhood Neurodevelopment among Residents near a Mining-Impacted Superfund Site. Environ Health Perspect 125:067020|
|Tamayo Y Ortiz, Marcela; Téllez-Rojo, Martha María; Trejo-Valdivia, Belem et al. (2017) Maternal stress modifies the effect of exposure to lead during pregnancy and 24-month old children's neurodevelopment. Environ Int 98:191-197|
|Lee, Jane J; Kapur, Kush; Rodrigues, Ema G et al. (2017) Anthropometric measures at birth and early childhood are associated with neurodevelopmental outcomes among Bangladeshi children aged 2-3years. Sci Total Environ 607-608:475-482|
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