The study of toxic heavy metals in the environment is challenging because metals are a natural component of our environment. As such, they have distinct biogeochemical cycles that govern their mobility, fate, and toxicity. A failure to understand these biogeochemical cycles will lead to a failure to adequately assess adverse impacts. Current risk assessment techniques for metals via the oral ingestion route are based on operationally defined tests which mimic the release of metals from soil in the human digestive system. A goal of this proposal is to be able to define the bioaccessibility of metals in geochemical terms, not based on operationally defined extraction methods. These goals will be tested through a combination of laboratory and in situ studies of metal-contaminated soils and mining wastes to characterize the interplay of processes that increase metal bioavailability over time and those that decrease metal bioavailability over time. Through these experiments, we will test whether the bioaccessibility of metals through oral ingestion can be predicted from the underlying speciation of metals and the characteristics of the soil itself. This study will bridge the current gap between geology and toxicology. Current risk assessment methods can determine if metals in a soil may exert risk, but not why. It is our intent to show that through the incorporation of a modest amount of geochemical analysis, we can greatly improve risk assessment for metals in soils by showing why some soils exert risk while other soils with similar levels of metals do not exert risk. In addition, with a similarly modest understanding of the temporal cycling of metals, we can show that bioaccessibility of metals in soils is not time invariant. With this knowledge, risk assessment can be proactive in understanding the nature of both current and future risks.

Public Health Relevance

The goals of this project directly align with the larger goals of the Superfund Basic Research Program. Our study is highly relevant to their Exposure Assessment Goals (we will develop tools to improve site assessment techniques through a better understanding of bioavailability), which in turn fits in with the goal of improving Risk Assessments at contaminated locations.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-LWJ-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Harvard University
United States
Zip Code
Burris, Heather H; Baccarelli, Andrea A; Motta, Valeria et al. (2014) Association between length of gestation and cervical DNA methylation of PTGER2 and LINE 1-HS. Epigenetics 9:1083-91
Kile, Molly L; Rodrigues, Ema G; Mazumdar, Maitreyi et al. (2014) A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh. Environ Health 13:29
Claus Henn, Birgit; Coull, Brent A; Wright, Robert O (2014) Chemical mixtures and children's health. Curr Opin Pediatr 26:223-9
Kile, Molly L; Houseman, E Andres; Baccarelli, Andrea A et al. (2014) Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics 9:774-82
Gleason, Kelsey; Shine, James P; Shobnam, Nadia et al. (2014) Contaminated turmeric is a potential source of lead exposure for children in rural Bangladesh. J Environ Public Health 2014:730636
Karwowski, Mateusz P; Just, Allan C; Bellinger, David C et al. (2014) Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study. Environ Health 13:77
Braun, Joseph M; Wright, Rosalind J; Just, Allan C et al. (2014) Relationships between lead biomarkers and diurnal salivary cortisol indices in pregnant women from Mexico City: a cross-sectional study. Environ Health 13:50
Fossati, Serena; Baccarelli, Andrea; Zanobetti, Antonella et al. (2014) Ambient particulate air pollution and microRNAs in elderly men. Epidemiology 25:68-78
Lee, Seunggeung; Abecasis, Gonçalo R; Boehnke, Michael et al. (2014) Rare-variant association analysis: study designs and statistical tests. Am J Hum Genet 95:5-23
Orenstein, Sara T C; Thurston, Sally W; Bellinger, David C et al. (2014) Prenatal organochlorine and methylmercury exposure and memory and learning in school-age children in communities near the New Bedford Harbor Superfund site, Massachusetts. Environ Health Perspect 122:1253-9

Showing the most recent 10 out of 30 publications