The Oregon State University Superfund Research Program (SRP) is multi-investigator, multi-disciplinary and multi-institutional. In partnership wit Pacific Northwest National Laboratories, and other stakeholders and collaborators, we seek to develop new technologies to assess polycyclic aromatic hydrocarbons (PAHs) found at many of the nation's Superfund sites and assess the risk they pose for human health. The SRP consists of three biomedical research projects, two non-biomedical research projects, Administrative, Research Translation, Community Engagement, Training and two research support cores (Biostatistics and Modeling and Chemistry). Over the next five years of the program a number of innovative and high impact research goals will be pursued including: (1) the first ever study of how humans take-up and excrete carcinogenic PAHs at environmental levels of exposure;(2) produce Physiologically Based Pharmacokinetic (PBPK) models for risk assessment of PAH mixtures;(3) determine developmental toxicities of PAH mixtures and PAHs formed in the environment using a zebrafish model;(4) employ passive sampling devices to assess bioavailable PAHs at Superfund sites and the effectiveness of remediation strategies and;(5) employ new analytical approaches to assessing chemical changes in PAHs in soilds and sediments at Superfund sites over time. The cores will: (1) direct the activities of the SRP (Administrative);(2) pursue effective mechanisms for disseminating our findings to stakeholders (Research Translation), (3) work with communities impacted by PAH exposure to address concerns and pursue solutions for reduced risk (Community Engagement);(4) provide intensive multi-disciplinary training opportunities for the next generation of Environmental Health Scientists (Training) and;(5 and 6) provide Biostatistical and Modeling support for the design, conduct and interpretation of the research being conducted as well as using state-of the-art Chemistry instrumentation and approaches to assess the identity and quantity of hundreds of PAHs found in environmental and biological matrices. Accomplishing these goals will provide significant scientific advancement and improve the quality of life for impacted communities.
PAHs are formed from the burning of coal, any petroleum product, tobacco, etc. PAHs are in significant amounts at almost half the nation's designated Superfund sites and are the primary driver for mediation at many of those sites. This SRP seeks to develop new technologies and research methodologies to assess the impact of PAHs on communities impacted by PAHs with the goal of reducing risk from exposure.
|Balik-Meisner, Michele; Truong, Lisa; Scholl, Elizabeth H et al. (2018) Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure. Environ Health Perspect 126:067010|
|Geier, Mitra C; James Minick, D; Truong, Lisa et al. (2018) Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol 354:115-125|
|Tan, Yu-Mei; Leonard, Jeremy A; Edwards, Stephen et al. (2018) Aggregate Exposure Pathways in Support of Risk Assessment. Curr Opin Toxicol 9:8-13|
|Titaley, Ivan A; Ogba, O Maduka; Chibwe, Leah et al. (2018) Automating data analysis for two-dimensional gas chromatography/time-of-flight mass spectrometry non-targeted analysis of comparative samples. J Chromatogr A 1541:57-62|
|Geier, Mitra C; Chlebowski, Anna C; Truong, Lisa et al. (2018) Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons. Arch Toxicol 92:571-586|
|Bugel, Sean M; Tanguay, Robert L (2018) Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish. Toxicol Appl Pharmacol 344:23-34|
|Garcia, Gloria R; Bugel, Sean M; Truong, Lisa et al. (2018) AHR2 required for normal behavioral responses and proper development of the skeletal and reproductive systems in zebrafish. PLoS One 13:e0193484|
|Roper, Courtney; Simonich, Staci L Massey; Tanguay, Robert L (2018) Development of a high-throughput in vivo screening platform for particulate matter exposures. Environ Pollut 235:993-1005|
|Haggard, Derik E; Noyes, Pamela D; Waters, Katrina M et al. (2018) Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists. Reprod Toxicol 77:80-93|
|Hummel, Jessica M; Madeen, Erin P; Siddens, Lisbeth K et al. (2018) Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food Chem Toxicol 115:136-147|
Showing the most recent 10 out of 174 publications