PROJECT SUMIVIARY (See instructions): The OSU SRP Training Core focuses on providing synergistic opportunities for graduate students, postdoctoral fellows, staff and newly hired faculty to develop the types of trans-disciplinary skill sets needed to address the challenges posed by the Superfund Program. We will train a new generation of transdisciplinaty scientists to address critical, complex problems of hazard assessment, environmental monitoring, and human health risk assessment for complex PAH mixtures and other contaminants present at Superfund Sites. The Training Core will specifically provide advanced pre- and post-doctoral training in PAH analysis, pharmacokinetics, systems-level toxicology, and risk assessment through the novel use of discoveries and new technologies emerging from our SRP research programs and support cores. An integrated educational experience that is focused on Superfund relevant issues will be constructed from individualized biomedical and non-biomedical didactic training combined with experiential learning opportunities that address SRP relevant issues. Such an approach will be complimented with both formal and informal opportunities for trainees in science communication and outreach activities. A distinctive aspect of our Training Core involves regional collaborations between Pacific Northwest SRPs (OSU, UC Davis and U. Washington) to substantially broaden the scope of SRP training experience through both shared and complimentaty training activities at each Center's Research Translation and Community Engagement Cores. Our training program will provide experiential opportunities in commercial, public health and regulatoty environments in addition to the traditional academic venues through innovative training partnerships with private risk-assessment firms, regulatoty agencies (EPA Region 10) and a local ecotoxicology contract laboratory generating data for commercial and government regulatory entities. Our trans-disciplinary program will prepare trainees to better understand the broad and complex challenges under investigation in our SRP during their tenure at OSU, as well as position the trainees for future careers in academic, industrial and environmental regulatory positions addressing Superfund issues.

Public Health Relevance

This training program will help synergize ongoing research projects at OSU and at other Superfund Research Programs and matriculate individuals with the highly integrated and trans-disciplinary skill sets able to work at the interface between traditional fields and nucleate interdisciplinary collaborative studies to solve complex environmental problems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES016465-05
Application #
8552226
Study Section
Special Emphasis Panel (ZES1-LWJ-D (SF))
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2013
Total Cost
$131,400
Indirect Cost
$41,400
Name
Oregon State University
Department
Type
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339
Knecht, Andrea L; Truong, Lisa; Simonich, Michael T et al. (2016) Developmental benzo[a]pyrene (B[a]P) exposure impacts larval behavior and impairs adult learning in zebrafish. Neurotoxicol Teratol :
Bugel, Sean M; Wehmas, Leah C; La Du, Jane K et al. (2016) Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicol Appl Pharmacol 296:31-41
Sadler, Natalie C; Nandhikonda, Premchendar; Webb-Robertson, Bobbie-Jo et al. (2016) Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development. Drug Metab Dispos 44:984-91
Haggard, Derik E; Noyes, Pamela D; Waters, Katrina M et al. (2016) Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. Toxicol Appl Pharmacol 308:32-45
Bugel, Sean M; Bonventre, Josephine A; Tanguay, Robert L (2016) Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System. Toxicol Sci 154:55-68
Paulik, L Blair; Smith, Brian W; Bergmann, Alan J et al. (2016) Passive samplers accurately predict PAH levels in resident crayfish. Sci Total Environ 544:782-91
Tidwell, Lane G; Allan, Sarah E; O'Connell, Steven G et al. (2016) PAH and OPAH Flux during the Deepwater Horizon Incident. Environ Sci Technol 50:7489-97
Garcia, Gloria R; Noyes, Pamela D; Tanguay, Robert L (2016) Advancements in zebrafish applications for 21st century toxicology. Pharmacol Ther 161:11-21
Zhang, Guozhu; Roell, Kyle R; Truong, Lisa et al. (2016) A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicol Appl Pharmacol 314:109-117
Truong, Lisa; Bugel, Sean M; Chlebowski, Anna et al. (2016) Optimizing multi-dimensional high throughput screening using zebrafish. Reprod Toxicol 65:139-147

Showing the most recent 10 out of 134 publications