Alcoholic liver and pancreatic diseases (ALPD) and cirrhosis constitute leading life-style diseases around the globe. The Southern California Research Center for ALPD and Cirrhosis unifies 57 investigators from major academic institutions in Southern California to pursue a common mission of being a leader in research, training, and outreach for the diseases. The center, since its inception in 1999, has devoted its efforts for development and use of clinically relevant animal models to gain novel insights into the molecular mechanisms underlying the predisposition to advanced ALPD. These efforts culminated to recent groundbreaking discoveries which have significantly advanced our understanding of synergistic ALPD caused by alcohol and a second hit. The center's interactive environment and infrastructure have facilitated in the past 5 years, a 152% increase in research base to $8.5M/year;4 new U01/P01 programs;198 publications;generation of 14 NIH-funded early-stage investigators;transition of 8 postdocs to faculty positions;training 166 graduate and 20 undergraduate students;and organizing 3 community seminars and 4 international symposia. As a unique national resource, the center has provided to scientific communities across the nation: 229 rodents as ALPD models and 241 model samples for 17 outside investigators;329 liver cell isolation preparations for 14 investigators;and support for grant acquisition and application by 12 outside investigators since the last renewal. The center will continue to strive as a unique scientific center of excellence in ALPD and cirrhosis by promoting: 1) environment conducive for leading-edge research on the center's theme: elucidation of the priming and sensitizing mechanisms for ALPD;2) provision of unique models, innovative genetic approaches and expertise to outside investigators including those at other NIAAA Alcohol Research Centers;3) comprehensive education and training to foster future generations of scientists in ALPD and cirrhosis;and 4) outreach efforts to disseminate the center's new findings to lay public, health care workers and scientists in our home and global communities.

Public Health Relevance

ALPD and cirrhosis are the major medical consequences of alcohol abuse and prevalent life-style diseases around the world. Our center's consorted efforts for research, training, and dissemination, and the outcome from these activities help advance the understanding of the diseases and develop novel preventive and therapeutic approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
2P50AA011999-16
Application #
8597083
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2014-02-01
Budget End
2014-12-31
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Eguchi, Akiko; Lazaro, Raul G; Wang, Jiaohong et al. (2017) Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology 65:475-490
Vollmann, Elisabeth H; Cao, Lizhi; Amatucci, Aldo et al. (2017) Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing. Mol Ther Nucleic Acids 7:314-323
Jang, Jung Eun; Park, Han-Sol; Yoo, Hyun Ju et al. (2017) Protective role of endogenous plasmalogens against hepatic steatosis and steatohepatitis in mice. Hepatology 66:416-431
Khanova, Elena; Wu, Raymond; Wang, Wen et al. (2017) Pyroptosis by Caspase11/4-Gasdermin-D Pathway in Alcoholic Hepatitis. Hepatology :
Arenas, Fabian; Garcia-Ruiz, Carmen; Fernandez-Checa, Jose C (2017) Intracellular Cholesterol Trafficking and Impact in Neurodegeneration. Front Mol Neurosci 10:382
García-Ruiz, Carmen; Ribas, Vicente; Baulies, Anna et al. (2017) Mitochondrial Cholesterol and the Paradox in Cell Death. Handb Exp Pharmacol 240:189-210
McDaniel, Kelly; Huang, Li; Sato, Keisaku et al. (2017) The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury. J Biol Chem 292:11336-11347
Koyama, Yukinori; Wang, Ping; Liang, Shuang et al. (2017) Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest 127:1254-1270
Setiawan, Veronica Wendy; Pandol, Stephen J; Porcel, Jacqueline et al. (2017) Dietary Factors Reduce Risk of Acute Pancreatitis in a Large Multiethnic Cohort. Clin Gastroenterol Hepatol 15:257-265.e3
Sheth, Sunil G; Conwell, Darwin L; Whitcomb, David C et al. (2017) Academic Pancreas Centers of Excellence: Guidance from a multidisciplinary chronic pancreatitis working group at PancreasFest. Pancreatology 17:419-430

Showing the most recent 10 out of 402 publications