The Administrative Core provides leadership and support to promote the highest quality research in the DEARC and its impact. The goals of the Administrative Core are to facilitate interactions among projects and attain research excellence throughout the DEARC by providing clear leadership, efficient management, effective committee structure, strong administrative, fiscal and research infrastructure, and the promotion of integrafion and synergism. These goals are supported through 5 aims.
Aim 1 provides an organizational infrastructure to facilitate attainment of Center goals and objectives through a strong Executive Committee (EC) consisting of the PI (L.Spear) and the two co-l's (T.Deak &S.Youngentob) of the Administrative Core, aided by an efficient DEARC office and administrator, capable fiscal support through the State University of New York Research Foundation (with offices at both Binghamton University [BU] and Upstate Medical University [UMU]), as well as strong institufional support and an impressive research infrastructure that includes new animal buildings on both DEARC campuses. Building on the culture of collaboration within the DEARC, Aim 2 promotes communication, facilitates interactions and encourages integration and synergisms across the DEARC through such activities as monthly meetings, mini-retreats, DEARC-sponsored colloquia, and a yearly retreat.
Aims 3 and 4 are to ensure oversight, coordinate interactions among research projects and cores, pronriote research-supportive allocation of resources, and utilize internal and external guidance committees to ensure quality and progress of research components and cores. Day-to-day decisions will be made by the EC with frequent consultation of a Steering Committee (composed of Pis of cores and main projects) and oversight by two critical guidance committees: an Internal Advisory Board (lAB) comprised of administrators at BU and UMU, and an External Advisory Board (EAB) comprised of nationally prominent senior alcohol researchers who serve as a program advisory committee to evaluate and advise the DEARC regarding all aspects of Center functioning.
Aim 5 is to encourage enrichment at all career levels, promote the recruitment of new researchers in the field of alcohol and development, and enhance outreach efforts.

Public Health Relevance

: The success of the Developmental Exposure Alcohol Research Center (DEARC) relies on an effective Administrative Core to facilitate interactions across the DEARC and promote the highest quality research in the area of alcohol and development. These goals will be accomplished through a strong Executive Committee, assisted by other internal and extemal committees, strong infrastmcture and institutional support, as well as the already established culture of collaboration within the DEARC.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Specialized Center (P50)
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Special Emphasis Panel (ZAA1)
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State University of NY, Binghamton
United States
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Gano, Anny; Doremus-Fitzwater, Tamara L; Deak, Terrence (2017) A cross-sectional comparison of ethanol-related cytokine expression in the hippocampus of young and aged Fischer 344 rats. Neurobiol Aging 54:40-53
Fernandez, Gina M; Lew, Brandon J; Vedder, Lindsey C et al. (2017) Chronic intermittent ethanol exposure leads to alterations in brain-derived neurotrophic factor within the frontal cortex and impaired behavioral flexibility in both adolescent and adult rats. Neuroscience 348:324-334
Vore, Andrew S; Doremus-Fitzwater, Tamara; Gano, Anny et al. (2017) Adolescent Ethanol Exposure Leads to Stimulus-Specific Changes in Cytokine Reactivity and Hypothalamic-Pituitary-Adrenal Axis Sensitivity in Adulthood. Front Behav Neurosci 11:78
Deak, Terrence; Kudinova, Anastacia; Lovelock, Dennis F et al. (2017) A multispecies approach for understanding neuroimmune mechanisms of stress. Dialogues Clin Neurosci 19:37-53
Gano, Anny; Pautassi, Ricardo Marcos; Doremus-Fitzwater, Tamara L et al. (2017) Conditioned effects of ethanol on the immune system. Exp Biol Med (Maywood) 242:718-730
Akinmboni, T O; Davis, N L; Falck, A J et al. (2017) Excipient exposure in very low birth weight preterm neonates. J Perinatol :
Lovelock, D F; Deak, T (2017) Repeated exposure to two stressors in sequence demonstrates that corticosterone and paraventricular nucleus of the hypothalamus interleukin-1? responses habituate independently. J Neuroendocrinol 29:
Gano, Anny; Doremus-Fitzwater, Tamara L; Deak, Terrence (2016) Sustained alterations in neuroimmune gene expression after daily, but not intermittent, alcohol exposure. Brain Res 1646:62-72
Diaz, Marvin R; Mooney, Sandra M; Varlinskaya, Elena I (2016) Acute prenatal exposure to ethanol on gestational day 12 elicits opposing deficits in social behaviors and anxiety-like behaviors in Sprague Dawley rats. Behav Brain Res 310:11-9
Fernandez, Gina M; Stewart, William N; Savage, Lisa M (2016) Chronic Drinking During Adolescence Predisposes the Adult Rat for Continued Heavy Drinking: Neurotrophin and Behavioral Adaptation after Long-Term, Continuous Ethanol Exposure. PLoS One 11:e0149987

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