The overarching goals of the Pilot Project Core are to (i) provide a structured funding mechanism to seed the development of great new ideas relevant to central themes of the DEARC;(ii) support career growth for both young and seasoned investigators through mentoring and facilitated collaboration;and (iii) capitalize on unique and timely opportunities that may arise from the rapidly changing, dynamic field of research on alcohol and development. The Pilot Project Core will achieve these goals through administration of a Pilot Project program that solicits Pilot Project Proposals from eligible investigators, coordinates the review process for proposals received, and ultimately oversees the award and reporting functions for all Pilot Projects. In addition, the Pilot Project Core, in close coordination with the Executive Committee, will help promote scientific connections among new members of the DEARC, and between these new members and established DEARC investigators to further increase scientific synergy and promote both peer-based and mentor-mentee relationships within the Center. Pilot Projects will be for 2 years each and funded at $30k (direct costs) each year. Using this approach, we will have a total of 6 funded pilot projects during the proposed 5-year funding period. Two highly innovative Pilot Project Proposals are proposed to begin in FY1. Pilot Project 1 (Cameron, PI) will examine the impact of maternal care during the neonatal period on DNA methylation and GABA-A receptor subunit expression, and how maternal care influences ethanol sensitivity later in life. Pilot Project 2 (Doremus-Fitzwater, PI) will examine the effect of adolescent ethanol exposure on coping behavior during aversive test situations, hypothesizing that adolescent ethanol exposure may differentially impact active versus passive coping strategies relative to adults. Through support of exciting new projects and promising investigators, the Pilot Project Core will serve as an incubator of great new ideas related to the central themes and mission of the DEARC.

Public Health Relevance

The Pilot Project Core will provide a critical framework for seeding new scientific projects that have the potential to develop into new programmatic lines of study in research areas relating to the central themes of the DEARC. The Pilot Project program will be used to draw new expertise into the DEARC, cultivate meaningful mentoring relationships for new DEARC members, and provide a means for the Center to remain responsive to new targeted opportunities that may arise during the 5 year funding period.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
2P50AA017823-06
Application #
8599544
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
State University of NY, Binghamton
Department
Type
DUNS #
City
Binghamton
State
NY
Country
United States
Zip Code
13902
Gano, Anny; Doremus-Fitzwater, Tamara L; Deak, Terrence (2017) A cross-sectional comparison of ethanol-related cytokine expression in the hippocampus of young and aged Fischer 344 rats. Neurobiol Aging 54:40-53
Fernandez, Gina M; Lew, Brandon J; Vedder, Lindsey C et al. (2017) Chronic intermittent ethanol exposure leads to alterations in brain-derived neurotrophic factor within the frontal cortex and impaired behavioral flexibility in both adolescent and adult rats. Neuroscience 348:324-334
Vore, Andrew S; Doremus-Fitzwater, Tamara; Gano, Anny et al. (2017) Adolescent Ethanol Exposure Leads to Stimulus-Specific Changes in Cytokine Reactivity and Hypothalamic-Pituitary-Adrenal Axis Sensitivity in Adulthood. Front Behav Neurosci 11:78
Deak, Terrence; Kudinova, Anastacia; Lovelock, Dennis F et al. (2017) A multispecies approach for understanding neuroimmune mechanisms of stress. Dialogues Clin Neurosci 19:37-53
Gano, Anny; Pautassi, Ricardo Marcos; Doremus-Fitzwater, Tamara L et al. (2017) Conditioned effects of ethanol on the immune system. Exp Biol Med (Maywood) 242:718-730
Akinmboni, T O; Davis, N L; Falck, A J et al. (2017) Excipient exposure in very low birth weight preterm neonates. J Perinatol :
Lovelock, D F; Deak, T (2017) Repeated exposure to two stressors in sequence demonstrates that corticosterone and paraventricular nucleus of the hypothalamus interleukin-1? responses habituate independently. J Neuroendocrinol 29:
Gano, Anny; Doremus-Fitzwater, Tamara L; Deak, Terrence (2016) Sustained alterations in neuroimmune gene expression after daily, but not intermittent, alcohol exposure. Brain Res 1646:62-72
Diaz, Marvin R; Mooney, Sandra M; Varlinskaya, Elena I (2016) Acute prenatal exposure to ethanol on gestational day 12 elicits opposing deficits in social behaviors and anxiety-like behaviors in Sprague Dawley rats. Behav Brain Res 310:11-9
Fernandez, Gina M; Stewart, William N; Savage, Lisa M (2016) Chronic Drinking During Adolescence Predisposes the Adult Rat for Continued Heavy Drinking: Neurotrophin and Behavioral Adaptation after Long-Term, Continuous Ethanol Exposure. PLoS One 11:e0149987

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