The overarching goals of the Pilot Project Core are to (i) provide a structured funding mechanism to seed the development of great new ideas relevant to central themes of the DEARC;(ii) support career growth for both young and seasoned investigators through mentoring and facilitated collaboration;and (iii) capitalize on unique and timely opportunities that may arise from the rapidly changing, dynamic field of research on alcohol and development. The Pilot Project Core will achieve these goals through administration of a Pilot Project program that solicits Pilot Project Proposals from eligible investigators, coordinates the review process for proposals received, and ultimately oversees the award and reporting functions for all Pilot Projects. In addition, the Pilot Project Core, in close coordination with the Executive Committee, will help promote scientific connections among new members of the DEARC, and between these new members and established DEARC investigators to further increase scientific synergy and promote both peer-based and mentor-mentee relationships within the Center. Pilot Projects will be for 2 years each and funded at $30k (direct costs) each year. Using this approach, we will have a total of 6 funded pilot projects during the proposed 5-year funding period. Two highly innovative Pilot Project Proposals are proposed to begin in FY1. Pilot Project 1 (Cameron, PI) will examine the impact of maternal care during the neonatal period on DNA methylation and GABA-A receptor subunit expression, and how maternal care influences ethanol sensitivity later in life. Pilot Project 2 (Doremus-Fitzwater, PI) will examine the effect of adolescent ethanol exposure on coping behavior during aversive test situations, hypothesizing that adolescent ethanol exposure may differentially impact active versus passive coping strategies relative to adults. Through support of exciting new projects and promising investigators, the Pilot Project Core will serve as an incubator of great new ideas related to the central themes and mission of the DEARC.

Public Health Relevance

The Pilot Project Core will provide a critical framework for seeding new scientific projects that have the potential to develop into new programmatic lines of study in research areas relating to the central themes of the DEARC. The Pilot Project program will be used to draw new expertise into the DEARC, cultivate meaningful mentoring relationships for new DEARC members, and provide a means for the Center to remain responsive to new targeted opportunities that may arise during the 5 year funding period.

Agency
National Institute of Health (NIH)
Type
Specialized Center (P50)
Project #
2P50AA017823-06
Application #
8599544
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
State University of NY, Binghamton
Department
Type
DUNS #
City
Binghamton
State
NY
Country
United States
Zip Code
13902
Mantella, Nicole M; Youngentob, Steven L (2014) Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats. PLoS One 9:e102255
Santerre, Jessica L; Gigante, Eduardo D; Landin, Justine D et al. (2014) Molecular and behavioral characterization of adolescent protein kinase C following high dose ethanol exposure. Psychopharmacology (Berl) 231:1809-20
Doremus-Fitzwater, Tamara L; Buck, Hollin M; Bordner, Kelly et al. (2014) Intoxication- and withdrawal-dependent expression of central and peripheral cytokines following initial ethanol exposure. Alcohol Clin Exp Res 38:2186-98
Gigante, Eduardo D; Santerre, Jessica L; Carter, Jenna M et al. (2014) Adolescent and adult rat cortical protein kinase A display divergent responses to acute ethanol exposure. Alcohol 48:463-70
Miranda-Morales, Roberto Sebastián; Nizhnikov, Michael E; Waters, Dustin H et al. (2014) New evidence of ethanol's anxiolytic properties in the infant rat. Alcohol 48:367-74
Fabio, Maria Carolina; Nizhnikov, Michael E; Spear, Norman E et al. (2014) Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats. Dev Psychobiol 56:574-83
Anderson, Rachel I; Morales, Melissa; Spear, Linda P et al. (2014) Pharmacological activation of kappa opioid receptors: aversive effects in adolescent and adult male rats. Psychopharmacology (Berl) 231:1687-93
Varlinskaya, Elena I; Mooney, Sandra M (2014) Acute exposure to ethanol on gestational day 15 affects social motivation of female offspring. Behav Brain Res 261:106-9
Nizhnikov, Michael E; Kozlov, Andrey P; Kramskaya, Tatiana A et al. (2014) Central effects of ethanol interact with endogenous mu-opioid activity to control isolation-induced analgesia in maternally separated infant rats. Behav Brain Res 260:119-30
Anderson, Rachel I; Spear, Linda P (2014) Age differences in ethanol discrimination: acquisition and ethanol dose generalization curves following multiple training conditions in adolescent and adult rats. Alcohol Clin Exp Res 38:186-94

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