The role of imaging technologies in dementia research is rapidly expanding. An imperative for noninvasive tools with early diagnostic capability - prior to the development of clinical signs/symptoms of dementia - has resulted from the development of effective forms of pharmacological and nonpharmacological therapy for Alzheimer's disease (AD). Neuroimaging data, especially when combined with clinical, neuropsychological, and genetic information may be uniquely useful for diagnosis and therapeutic monitoring, as well as guiding further drug discovery. The Neuroimaging Core (Core F) will continue to support structural and functional magnetic resonance imaging (MRI) in ADRC participants and provide the infrastructure for developing state-of-the-art MRI and functional MRI (fMRI) in aging and dementia. The Core will further assist in the expansion of the role of positron emission tomography (PET) studies of aging and dementia by focusing on the recent development of Pittsburgh Compound B (PiB), a marker for brain beta-amyloid deposition. The Core has implemented and maintained efficient procedures for acquiring, archiving, and interpreting MRI examinations performed as part of the ADRC patient evaluation. The Neuroimaging Core is accruing similar MRI examinations in healthy elderly comparison subjects, as emphasized by our external advisors, and we have further established a normative database of structural MRI data that is available to ADRC and related investigators. During the next five years, the Neuroimaging Core will continue to develop and distribute technology for acquiring and interpreting structural and functional image data in support of AD research. The Core will advance the overall goals of the Center by supporting and promoting research that increases our understanding of the etiology and pathogenesis of AD and to facilitate new therapies and therapeutic monitoring.

Public Health Relevance

The ability to visualize the brain of a living person is critical for the accurate diagnosis of Alzheimer's disease and related dementias. This Core is responsible for obtaining such images using stae-of-the-art technologies, and for maintaining a library of the images. We will also work with the other scientists at the ADRC to help them develop new ways to analyse these images, which will help them complete their studies of aging and dementia.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
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Special Emphasis Panel (ZAG1-ZIJ-4)
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University of Pittsburgh
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Flatt, Jason D; Liptak, Amy; Oakley, Mary Ann et al. (2015) Subjective experiences of an art museum engagement activity for persons with early-stage Alzheimer's disease and their family caregivers. Am J Alzheimers Dis Other Demen 30:380-9
Wang, Xingbin; Lopez, Oscar L; Sweet, Robert A et al. (2015) Genetic determinants of disease progression in Alzheimer's disease. J Alzheimers Dis 43:649-55
Klunk, William E; Koeppe, Robert A; Price, Julie C et al. (2015) The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement 11:1-15.e1-4
Hu, Wei; MacDonald, Matthew L; Elswick, Daniel E et al. (2015) The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies. Ann N Y Acad Sci 1338:38-57
Riverol, Mario; Becker, James T; López, Oscar L et al. (2015) Relationship between Systemic and Cerebral Vascular Disease and Brain Structure Integrity in Normal Elderly Individuals. J Alzheimers Dis 44:319-28
Chaudhry, Mamoonah; Wang, Xingbin; Bamne, Mikhil N et al. (2015) Genetic variation in imprinted genes is associated with risk of late-onset Alzheimer's disease. J Alzheimers Dis 44:989-94
Sanders, Laurie H; McCoy, Jennifer; Hu, Xiaoping et al. (2014) Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease. Neurobiol Dis 70:214-23
Raji, Cyrus A; Erickson, Kirk I; Lopez, Oscar L et al. (2014) Regular fish consumption and age-related brain gray matter loss. Am J Prev Med 47:444-51
Hong, Young T; Veenith, Tonny; Dewar, Deborah et al. (2014) Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury. JAMA Neurol 71:23-31
Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606

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