The role of imaging technologies in dementia research is rapidly expanding. An imperative for noninvasive tools with early diagnostic capability - prior to the development of clinical signs/symptoms of dementia - has resulted from the development of effective forms of pharmacological and nonpharmacological therapy for Alzheimer's disease (AD). Neuroimaging data, especially when combined with clinical, neuropsychological, and genetic information may be uniquely useful for diagnosis and therapeutic monitoring, as well as guiding further drug discovery. The Neuroimaging Core (Core F) will continue to support structural and functional magnetic resonance imaging (MRI) in ADRC participants and provide the infrastructure for developing state-of-the-art MRI and functional MRI (fMRI) in aging and dementia. The Core will further assist in the expansion of the role of positron emission tomography (PET) studies of aging and dementia by focusing on the recent development of Pittsburgh Compound B (PiB), a marker for brain beta-amyloid deposition. The Core has implemented and maintained efficient procedures for acquiring, archiving, and interpreting MRI examinations performed as part of the ADRC patient evaluation. The Neuroimaging Core is accruing similar MRI examinations in healthy elderly comparison subjects, as emphasized by our external advisors, and we have further established a normative database of structural MRI data that is available to ADRC and related investigators. During the next five years, the Neuroimaging Core will continue to develop and distribute technology for acquiring and interpreting structural and functional image data in support of AD research. The Core will advance the overall goals of the Center by supporting and promoting research that increases our understanding of the etiology and pathogenesis of AD and to facilitate new therapies and therapeutic monitoring.

Public Health Relevance

The ability to visualize the brain of a living person is critical for the accurate diagnosis of Alzheimer's disease and related dementias. This Core is responsible for obtaining such images using stae-of-the-art technologies, and for maintaining a library of the images. We will also work with the other scientists at the ADRC to help them develop new ways to analyse these images, which will help them complete their studies of aging and dementia.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
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Special Emphasis Panel (ZAG1-ZIJ-4)
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University of Pittsburgh
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Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Qiu, Shangran; Chang, Gary H; Panagia, Marcello et al. (2018) Fusion of deep learning models of MRI scans, Mini-Mental State Examination, and logical memory test enhances diagnosis of mild cognitive impairment. Alzheimers Dement (Amst) 10:737-749
DeMichele-Sweet, M A A; Weamer, E A; Klei, L et al. (2018) Genetic risk for schizophrenia and psychosis in Alzheimer disease. Mol Psychiatry 23:963-972
Jansen, Willemijn J; Ossenkoppele, Rik; Tijms, Betty M et al. (2018) Association of Cerebral Amyloid-? Aggregation With Cognitive Functioning in Persons Without Dementia. JAMA Psychiatry 75:84-95
Di Maio, Roberto; Hoffman, Eric K; Rocha, Emily M et al. (2018) LRRK2 activation in idiopathic Parkinson's disease. Sci Transl Med 10:
Wilckens, Kristine A; Tudorascu, Dana L; Snitz, Beth E et al. (2018) Sleep moderates the relationship between amyloid beta and memory recall. Neurobiol Aging 71:142-148

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