Abstract

Core G: Neurogenetics Abstract The Neurogenetics Core builds on the strengths of genetics of dementia at the University of Pittsburgh. Genetics studies as part of the University of Pittsburgh Alzheimer's Disease Research Center (PITT-ADRC) were started by Dr. Kamboh (Core Leader) in 1995 when we initiated blood collection and APOE genotyping on all participants of the PITT-ADRC. In addition to collecting blood samples from PITT- ADRC participants, we collect blood samples from ADRC and non-ADRC ancillary studies that provide additional well-characterized older controls essential for genetic association studies and endophenotype data that would help to identify novel genes for dementia. The resources built by the PITT-ADRC Neurogenetics Core have contributed to the identification of several new genes for AD and also have served as an educational and training hub for graduate students and junior faculty at the University of Pittsburgh. The goal of the PITT-ADRC Neurogenetics Core is to continue collecting and archiving DNA and blood samples from new and existing AD patients and controls in order to enlarge our case-control and family sample and to augment the amount of existing DNA that would be critical to future efforts in identifying new genes/variants for AD. DNA and genotype (APOE and new risk markers) data will be provided to investigators upon request.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005133-33
Application #
9064037
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
33
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Kamboh, M Ilyas (2018) A Brief Synopsis on the Genetics of Alzheimer's Disease. Curr Genet Med Rep 6:133-135
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
La Joie, Renaud; Ayakta, Nagehan; Seeley, William W et al. (2018) Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimers Dement :
Rodakowski, Juleen; Reynolds 3rd, Charles F; Lopez, Oscar L et al. (2018) Developing a Non-Pharmacological Intervention for Individuals With Mild Cognitive Impairment. J Appl Gerontol 37:665-676
Pottier, Cyril; Zhou, Xiaolai; Perkerson 3rd, Ralph B et al. (2018) Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol 17:548-558
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Ritzel, Rodney M; Lai, Yun-Ju; Crapser, Joshua D et al. (2018) Aging alters the immunological response to ischemic stroke. Acta Neuropathol 136:89-110
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Cohen, Ann D; McDade, Eric; Christian, Brad et al. (2018) Early striatal amyloid deposition distinguishes Down syndrome and autosomal dominant Alzheimer's disease from late-onset amyloid deposition. Alzheimers Dement 14:743-750

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