The Overall Goal of the MADRC Clinical Core is to establish and maintain a cohort of men and women of diverse ethnic and racial backgrounds who will join us in conducting research into the cause, prevention and cure degenerative brain diseases. The composition of the cohort, which we call the Longitudinal Cohort on Brain Aging and Dementia, will include elderly individuals with normal cognition, individuals with mild cognitive impairment and other mild deficits, and individuals with a range of dementias including Alzheimer's disease, Lewy body diseases (including Parkinson's disease, Parkinson's with dementia and dementia with Lewy bodies), and frontotemporal dementia. The composition of this cohort will enable us to detect the earliest cognitive and behavioral changes associated with Alzheimer's disease and related dementias and to track their evolution over time. The cohort will also serve as a reservoir of individuals who are interested and willing to participate in local and national research projects.
The Specific Aims of the Core are to: 1) Recruit into the Longitudinal Cohort 600 individuals spanning the spectrum of cognition from normal elderly to mild cognitive impairment to dementia;2) Examine these individuals with comprehensive assessments that include the full Uniform Data Set, which are submitted to NACC;3) Establish a Genetics and Biomarker Program to collect and store biological fluid samples for biochemical, molecular and genetic studies;4) Expand the Neuroimaging Program to archive all MR and PET scans on Cohort subjects and to support ongoing projects within the MADRC;5) Characterize the neurological, psychiatric and neuropsychological features of all Cohort participants annually, and link these data to their collected biomarker and neuroimaging data;6) Refer Cohort participants to specific research projects within the MADRC and to national ADC and other multi-site investigations;7) Facilitate brain autopsies and, working with the Neuropathology Core, direct clinical-pathological correlations;8) Train new investigators in dementia research;and 9) In concert with the Education and Information Core, promote dementia awareness among lay and professional groups and offer research opportunities to underserved minority groups.

Public Health Relevance

}: Developing cognitive impairments and frank dementia are among the most feared consequences of aging. Staffs in the Clinical Core of the MADRC are dedicated to partnering with men and women who will join us in research studies into the causes, course, treatment and eventual prevention of dementia.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts General Hospital
United States
Zip Code
Mattos, Meghan K; Snitz, Beth E; Lingler, Jennifer H et al. (2017) Older Rural- and Urban-Dwelling Appalachian Adults With Mild Cognitive Impairment. J Rural Health 33:208-216
Moga, Daniela C; Abner, Erin L; Wu, Qishan et al. (2017) Bladder antimuscarinics and cognitive decline in elderly patients. Alzheimers Dement (N Y) 3:139-148
Wachinger, Christian; Reuter, Martin; Klein, Tassilo (2017) DeepNAT: Deep convolutional neural network for segmenting neuroanatomy. Neuroimage :
Sennik, Simrin; Schweizer, Tom A; Fischer, Corinne E et al. (2017) Risk Factors and Pathological Substrates Associated with Agitation/Aggression in Alzheimer's Disease: A Preliminary Study using NACC Data. J Alzheimers Dis 55:1519-1528
Marquié, Marta; Verwer, Eline E; Meltzer, Avery C et al. (2017) Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case. Acta Neuropathol Commun 5:75
Wang, Zemin; Jackson, Rosemary J; Hong, Wei et al. (2017) Human Brain-Derived A? Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP. J Neurosci 37:11947-11966
Liu, Ganqiang; Locascio, Joseph J; Corvol, Jean-Christophe et al. (2017) Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts. Lancet Neurol 16:620-629
Neu, Scott C; Pa, Judy; Kukull, Walter et al. (2017) Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis. JAMA Neurol 74:1178-1189
Xia, Chenjie; Makaretz, Sara J; Caso, Christina et al. (2017) Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurol 74:427-436
Dickerson, Bradford C; McGinnis, Scott M; Xia, Chenjie et al. (2017) Approach to atypical Alzheimer's disease and case studies of the major subtypes. CNS Spectr 22:439-449

Showing the most recent 10 out of 858 publications