The Administrative Core's goals are to set the overall direction for the Center, ensure optimal utilization of Center resources, and provide a sense of """"""""Centerness"""""""". The Massachusetts ADRC's goals are to provide the infrastructure and environment to enhance and facilitate cutting-edge basic, translational, and clinical research in Alzheimer disease and related disorders, as well as provide a unique and exciting training environment for the next generation of clinicians and scientists working in these arenas.
Our aims are outlined in the RFA, and include creating an administrative structure and infrastructure to facilitate the work of the Center. This includes administrative support for the Mass. ADRC's Clinical, Data Management and Statistics, Neuropathology, Education and Information Transfer Cores and research projects. We provide formal mechanisms to augment collaborative activities with the scientific and lay communities, and to enhance collaborations across departments, units, local institutions, and national efforts to create an energetic multi- and cross-disciplinary approach to understanding AD. The Administrative Core will also provide fiscal accountability and business management expertise for the Center, and ensure compliance with institutional, NIH and HIPAA policies and requirements related to human subjects and animal research. A second major effort of the Administrative Core is to organize 4 major Committee programs: An Executive Committee consisting of Core and Project leaders and additional Key Personnel, to advise the Director on scientific and administrative matters;an External Advisory Board to provide guidance to the Center on an annual basis;a Pilot Project Review Committee to recommend 3 pilot projects on an annual basis;and an Internal Advisory Board consisting of senior scientists, clinicians, and administrators from our constituent institutions to coordinate ADRC efforts with local resources. Additional committees and infrastructure are described to recruit pilot projects, to co-ordinate IRB approvals for projects, to coordinate recruitment of subjects for studies, and to monitor the scientific and administrative functions of the Center.
The Administrative Core of the Massachusetts ADRC provides the infrastructure and management of resources to enhance the training environment for clinical research in Alzheimer's disease and related disorders.
|Viswanathan, Anand; Greenberg, Steven M; Scheltens, Philip (2016) Role of Vascular Disease in Alzheimer-Like Progressive Cognitive Impairment. Stroke 47:577-80|
|Dhilla Albers, Alefiya; Asafu-Adjei, Josephine; Delaney, Mary K et al. (2016) Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly. Ann Neurol 80:846-857|
|Day, Gregory S; Musiek, Erik S; Roe, Catherine M et al. (2016) Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. JAMA Neurol 73:1125-32|
|Ronquillo, Jay Geronimo; Baer, Merritt Rachel; Lester, William T (2016) Sex-specific patterns and differences in dementia and Alzheimer's disease using informatics approaches. J Women Aging 28:403-11|
|Herold, C; Hooli, B V; Mullin, K et al. (2016) Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3. Mol Psychiatry 21:1608-1612|
|Serrano-Pozo, Alberto; Betensky, Rebecca A; Frosch, Matthew P et al. (2016) Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. Am J Pathol 186:375-84|
|Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-20|
|Ringman, John M; Monsell, Sarah; Ng, Denise W et al. (2016) Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol 75:284-90|
|Grogg, Kira S; Toole, Terrence; Ouyang, Jinsong et al. (2016) National Electrical Manufacturers Association and Clinical Evaluation of a Novel Brain PET/CT Scanner. J Nucl Med 57:646-52|
|Rentz, Dorene M; Dekhtyar, Maria; Sherman, Julia et al. (2016) The Feasibility of At-Home iPad Cognitive Testing For Use in Clinical Trials. J Prev Alzheimers Dis 3:8-12|
Showing the most recent 10 out of 717 publications