The Overall Goal of the MADRC Clinical Core is to establish and maintain a cohort of men and women of diverse ethnic and racial backgrounds who will join us in conducting research into the cause, prevention and cure degenerative brain diseases. The composition of the cohort, which we call the Longitudinal Cohort on Brain Aging and Dementia, will include elderly individuals with normal cognition, individuals with mild cognitive impairment and other mild deficits, and individuals with a range of dementias including Alzheimer's disease, Lewy body diseases (including Parkinson's disease, Parkinson's with dementia and dementia with Lewy bodies), and frontotemporal dementia. The composition of this cohort will enable us to detect the earliest cognitive and behavioral changes associated with Alzheimer's disease and related dementias and to track their evolution over time. The cohort will also serve as a reservoir of individuals who are interested and willing to participate in local and national research projects.
The Specific Aims of the Core are to: 1) Recruit into the Longitudinal Cohort 600 individuals spanning the spectrum of cognition from normal elderly to mild cognitive impairment to dementia;2) Examine these individuals with comprehensive assessments that include the full Uniform Data Set, which are submitted to NACC;3) Establish a Genetics and Biomarker Program to collect and store biological fluid samples for biochemical, molecular and genetic studies;4) Expand the Neuroimaging Program to archive all MR and PET scans on Cohort subjects and to support ongoing projects within the MADRC;5) Characterize the neurological, psychiatric and neuropsychological features of all Cohort participants annually, and link these data to their collected biomarker and neuroimaging data;6) Refer Cohort participants to specific research projects within the MADRC and to national ADC and other multi-site investigations;7) Facilitate brain autopsies and, working with the Neuropathology Core, direct clinical-pathological correlations;8) Train new investigators in dementia research;and 9) In concert with the Education and Information Core, promote dementia awareness among lay and professional groups and offer research opportunities to underserved minority groups.

Public Health Relevance

}: Developing cognitive impairments and frank dementia are among the most feared consequences of aging. Staffs in the Clinical Core of the MADRC are dedicated to partnering with men and women who will join us in research studies into the causes, course, treatment and eventual prevention of dementia.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005134-30
Application #
8448157
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
30
Fiscal Year
2013
Total Cost
$553,860
Indirect Cost
$117,751
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Ward, Andrew M; Mormino, Elizabeth C; Huijbers, Willem et al. (2015) Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits. Neurobiol Aging 36:265-72
Aganj, Iman; Reuter, Martin; Sabuncu, Mert R et al. (2015) Avoiding symmetry-breaking spatial non-uniformity in deformable image registration via a quasi-volume-preserving constraint. Neuroimage 106:238-51
Bickart, Kevin C; Brickhouse, Michael; Negreira, Alyson et al. (2014) Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to social impairments measured using the Social Impairment Rating Scale. J Neurol Neurosurg Psychiatry 85:438-48
Riascos, David; Nicholas, Alexander; Samaeekia, Ravand et al. (2014) Alterations of Ca²?-responsive proteins within cholinergic neurons in aging and Alzheimer's disease. Neurobiol Aging 35:1325-33
Papp, Kathryn V; Amariglio, Rebecca E; Dekhtyar, Maria et al. (2014) Development of a psychometrically equivalent short form of the Face-Name Associative Memory Exam for use along the early Alzheimer's disease trajectory. Clin Neuropsychol 28:771-85
Jackson, John W; Schneeweiss, Sebastian; VanderWeele, Tyler J et al. (2014) Quantifying the role of adverse events in the mortality difference between first and second-generation antipsychotics in older adults: systematic review and meta-synthesis. PLoS One 9:e105376
Schultz, Aaron P; Chhatwal, Jasmeer P; Huijbers, Willem et al. (2014) Template based rotation: a method for functional connectivity analysis with a priori templates. Neuroimage 102 Pt 2:620-36
Spires-Jones, Tara L; Friedman, Taylor; Pitstick, Rose et al. (2014) Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neurosci Lett 562:63-8
Mormino, Elizabeth C; Betensky, Rebecca A; Hedden, Trey et al. (2014) Amyloid and APOE ?4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology 82:1760-7
Stoub, Travis R; Detoledo-Morrell, Leyla; Dickerson, Bradford C (2014) Parahippocampal white matter volume predicts Alzheimer's disease risk in cognitively normal old adults. Neurobiol Aging 35:1855-61

Showing the most recent 10 out of 440 publications