The Data Management and Statistics Core provides the database and statistical support for research conducted in conjunction with the ADRC, including local projects and collaborative efforts with other ADCs and with national AD research initiatives. This includes database development and maintenance, data quality control and monitoring, study design and planning, and data analysis and interpretation. The Core will ensure adherence to the highest standards of database and statistical practice. Development of novel study designs to maximize the efficiency of early disease trials is a major research focus. A new focus of the Core is the training of biostatisticians with expertise in statistical methods that are necessary to solve analytic issues that arise in laboratory, clinical and epidemiologic studies of AD, and the training of physician- scientists with a mastery of epidemiologic and biostatistical principles of study design and clinical research. An additional new focus of the Core is development and deployment of novel software for integrating multimodal data and interpretations. This takes two forms: advanced longitudinal and multimodal database software, and software to support web-based collaboration amongst ADRC and collaborating researchers.
The specific aims of the Core are: (1) To provide computing and (a) database management and (b) statistical consultation and collaboration to the research projects, pilot projects and the cores of the ADRC;(2) To facilitate local research efforts, collaborations between and among ADCs, and with national AD research initiatives, including NACC. This includes preparing the Uniform Data Set (UDS) for transmission to NACC; (3) To develop, implement and share novel specialized software for multimodal database integration and query and provide training for users in the software and database;(4) To provide software support for the ADRC web page, including web-based collaboration amongst ADRC researchers;and to provide training for users in the software;(5) To train students in the Biostatistics and Epidemiology Departments at Harvard School of Public Health in statistical and epidemiologic methods that are required for AD studies. Also, to train junior clinical investigators in the principles and methods of clinjcal AD research;(6) To develop efficient clinical trial designs for the study of early stage patients, drawing upon analyses of existing cohorts with long follow-up, with validation in the NACC database;(7) To develop methods for analysis of observational data that properly account for selection bias due to nonrandom ascertainment and complex forms of truncation.

Public Health Relevance

}: The Data Management and Statistics Core is responsible for entering, managing, transferring, and analyzing all ADRC related data. The Core trains investigators to use its database software and web-based tools. It also provides training in statistical methods for the design and analysis of Alzheimer's studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005134-30
Application #
8448158
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
30
Fiscal Year
2013
Total Cost
$170,933
Indirect Cost
$36,341
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Ward, Andrew M; Mormino, Elizabeth C; Huijbers, Willem et al. (2015) Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits. Neurobiol Aging 36:265-72
Aganj, Iman; Reuter, Martin; Sabuncu, Mert R et al. (2015) Avoiding symmetry-breaking spatial non-uniformity in deformable image registration via a quasi-volume-preserving constraint. Neuroimage 106:238-51
Bickart, Kevin C; Brickhouse, Michael; Negreira, Alyson et al. (2014) Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to social impairments measured using the Social Impairment Rating Scale. J Neurol Neurosurg Psychiatry 85:438-48
Riascos, David; Nicholas, Alexander; Samaeekia, Ravand et al. (2014) Alterations of Ca²?-responsive proteins within cholinergic neurons in aging and Alzheimer's disease. Neurobiol Aging 35:1325-33
Papp, Kathryn V; Amariglio, Rebecca E; Dekhtyar, Maria et al. (2014) Development of a psychometrically equivalent short form of the Face-Name Associative Memory Exam for use along the early Alzheimer's disease trajectory. Clin Neuropsychol 28:771-85
Jackson, John W; Schneeweiss, Sebastian; VanderWeele, Tyler J et al. (2014) Quantifying the role of adverse events in the mortality difference between first and second-generation antipsychotics in older adults: systematic review and meta-synthesis. PLoS One 9:e105376
Schultz, Aaron P; Chhatwal, Jasmeer P; Huijbers, Willem et al. (2014) Template based rotation: a method for functional connectivity analysis with a priori templates. Neuroimage 102 Pt 2:620-36
Spires-Jones, Tara L; Friedman, Taylor; Pitstick, Rose et al. (2014) Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neurosci Lett 562:63-8
Mormino, Elizabeth C; Betensky, Rebecca A; Hedden, Trey et al. (2014) Amyloid and APOE ?4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology 82:1760-7
Stoub, Travis R; Detoledo-Morrell, Leyla; Dickerson, Bradford C (2014) Parahippocampal white matter volume predicts Alzheimer's disease risk in cognitively normal old adults. Neurobiol Aging 35:1855-61

Showing the most recent 10 out of 440 publications