The Clinical Core (Core B) of the Johns Hopkins Alzheimer's Disease Research Center (ADRC) will be responsible for recruiting and following a diverse group of research subjects to support research projects associated with the ADRC. The Clinical Core accomplishes this overarching goal working closely with ADRC leadership and with the other Cores and Projects. The subjects in the Core include: (1) cognitively normal controls, (2) subjects meeting criteria for Mild Cognitive Impaimient (MCI), (3) patients with Alzheimer's disease (AD), and (4) patients with other related dementias. These cohorts include subjects recruited through the Clinic at Johns Hopkins Medical Institutions (known as the 'Clinic Cohort') as well as the subjects recruited through the Baltimore Longitudinal Study on Aging (BLSA) (known as the 'BLSA Cohort'). These subjects receive annual, standardized medical, neurologic, psychiatric and neuropsychological evaluations. Well-characterized, diverse subjects will be made available to research projects associated with the ADRC, working closely with the Education Core. The Clinical Core will work with the Neuropathology Core to collect, store and analyze plasma, serum, CSF, and DNA from normal controls, individuals with MCI, and cases of AD and related dementias, and to complete APOE genotyping on subjects. Core B will work closely with Core E and Core D to maintain a high autopsy rate (greater than 70%). Investigators in Core B will participate in collaborative research with other AD Centers, including multi-center therapeutic clinical trials related to AD. Core B will work with Core C to provide clinical data to the National Alzheimer's Coordinating Center (NACC) to further interdisciplinary research in AD.

Public Health Relevance

The Johns Hopkins Alzheimer's Disease Research Center (ADRC) will address many of the topics important to dementia research, with a particular focus on the understanding the earliest phases of Alzheimer's disease (AD). This approach is important if we are ultimately going to be able to diagnose and treat AD as early as possible. The ADRC fosters interactions among scientists who are pursuing this overarching theme.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
United States
Zip Code
Gracia-Garcia, Patricia; de-la-Camara, Concepcion; Santabarbara, Javier et al. (2015) Depression and incident Alzheimer disease: the impact of disease severity. Am J Geriatr Psychiatry 23:119-29
Marano, Christopher M; Workman, Clifford I; Lyman, Christopher H et al. (2015) Structural imaging in late-life depression: association with mood and cognitive responses to antidepressant treatment. Am J Geriatr Psychiatry 23:12-Apr
Ning, Jing; Bandeen-Roche, Karen (2014) Estimation of time-dependent association for bivariate failure times in the presence of a competing risk. Biometrics 70:10-20
Reagh, Zachariah M; Roberts, Jared M; Ly, Maria et al. (2014) Spatial discrimination deficits as a function of mnemonic interference in aged adults with and without memory impairment. Hippocampus 24:303-14
Ho, Cheng-Ying; Troncoso, Juan C; Knox, David et al. (2014) Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients. Brain Pathol 24:25-32
Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606
Leal, Stephanie L; Tighe, Sarah K; Jones, Craig K et al. (2014) Pattern separation of emotional information in hippocampal dentate and CA3. Hippocampus 24:1146-55
Ayers, Jacob I; Xu, Guilian; Pletnikova, Olga et al. (2014) Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases. Acta Neuropathol Commun 2:55
Semba, Richard D; Moghekar, Abhay R; Hu, Jason et al. (2014) Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease. Neurosci Lett 558:37-40
Wendell, Carrington R; Waldstein, Shari R; Zonderman, Alan B (2014) Nonlinear longitudinal trajectories of cholesterol and neuropsychological function. Neuropsychology 28:106-12

Showing the most recent 10 out of 320 publications