The Education Core (Core E) of the Johns Hopkins Alzheimer's Disease Research Center (ADRC) has several overarching goals: (1) To augment mechanisms for recruiting and retaining subjects into the clinical research activities of the ADRC, and to assure that this subject population reflects the ethnic and racial diversity of the Greater Baltimore area. (2) To increase the knowledge about AD and related disorders among patients, caregivers and other community members concerning: (a) diagnosis and management of AD and related disorders, (b) age-related changes of cognition and risk factors for cognitive decline, and (c) signs and symptoms of mild cognitive impairment, and the transition to dementia. (3) To expand educational opportunities for professionals at all stages of development, including: medical students, residents, post-doctoral fellows, junior faculty and established clinicians, as well as those in allied professions, such as nursing and social work. In this context, it is especially important to develop educational opportunities for clinicians that provide care to underserved segments ofthe community. In the current funding cycle, we have utilized a set of educational principals in order to help us establish priorities, and to plan and evaluate our programs. Through the efforts of the Education Core, working with the Clinical Core, we have been able to increase minority enrollment in the Clinic Cohort from 16% to 26%. In the next funding cycle, we will aim to maintain this diverse group of subjects and to encourage their participation in projects associated with the ADRC and participate in ante-mortem autopsy approval. During the current funding cycle, the Education Core has also provided a wide variety of educational programs for the lay public and for professionals. We will continue to evaluate these programs to assure they are meeting their programmatic aims and will initiate new programs that address the mission of the ADRC and educational efforts related to AD and related disorders throughout the U.S. more broadly.

Public Health Relevance

The Johns Hopkins Alzheimer's Disease Research Center (ADRC) will address many of the topics important to dementia research, with a particular focus on the understanding the eariiest phases of Alzheimer's disease (AD). This approach is important if we are ultimately going to be able to diagnose and treat AD as eariy as possible. The ADRC fosters interactions among scientists who are pursuing this overarching theme.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005146-31
Application #
8662620
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
31
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Bouhrara, Mustapha; Reiter, David A; Bergeron, Christopher M et al. (2018) Evidence of demyelination in mild cognitive impairment and dementia using a direct and specific magnetic resonance imaging measure of myelin content. Alzheimers Dement 14:998-1004
Xiong, Yulan; Neifert, Stewart; Karuppagounder, Senthilkumar S et al. (2018) Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proc Natl Acad Sci U S A 115:1635-1640
Nicolas, Aude (see original citation for additional authors) (2018) Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron 97:1268-1283.e6
Wong, Dean F; Comley, Robert A; Kuwabara, Hiroto et al. (2018) Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects. J Nucl Med 59:1869-1876
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307
Varma, Vijay R; Oommen, Anup M; Varma, Sudhir et al. (2018) Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study. PLoS Med 15:e1002482
Zhou, Zilu; Wang, Weixin; Wang, Li-San et al. (2018) Integrative DNA copy number detection and genotyping from sequencing and array-based platforms. Bioinformatics 34:2349-2355
Soldan, Anja; Pettigrew, Corinne; Albert, Marilyn (2018) Evaluating Cognitive Reserve Through the Prism of Preclinical Alzheimer Disease. Psychiatr Clin North Am 41:65-77
Guerreiro, Rita; Ross, Owen A; Kun-Rodrigues, Celia et al. (2018) Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. Lancet Neurol 17:64-74
Bermudez, Camilo; Plassard, Andrew J; Davis, Taylor L et al. (2018) Learning Implicit Brain MRI Manifolds with Deep Learning. Proc SPIE Int Soc Opt Eng 10574:

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