The Data Management and Statistics Core (Core C) of the Johns Hopkins Alzheimer's Disease Research Center (ADRC) has two overarching goals: (1) to provide database design, data management and data distribution for investigators associated with the ADRC, (2) to provide statistical expertise to investigators associated with the ADRC, including consultation to projects associated with the ADRC, development of novel analytic methods, and mentoring young statisticians. Through the provision of efficient database design and data management, Core C assures the accuracy, accessibility, and integration of data from the ADRC, and provides data sets to the National Alzheimer's Coordinating Center (NACC) and to investigators associated with the ADRC, both within the institution and at other ADC sites. Through the provision of high level statistical consultation to investigators associated with the Center, a range of projects related to the ADRC have been facilitated, novel methods have been developed, and young investigators have been trained in longitudinal methods related to cognitive decline and dementia. In the next funding cycle the Data Management and Statistics Core will continue with these aims.

Public Health Relevance

The Johns Hopkins Alzheimer's Disease Research Center (ADRC) will address many of the topics important to dementia research, with a particular focus on the understanding the earliest phases of Alzheimer's disease (AD). This approach is important if we are ultimately going to be able to diagnose and treat AD as early as possible. The ADRC fosters interactions among scientists who are pursuing this overarching theme.

Agency
National Institute of Health (NIH)
Type
Specialized Center (P50)
Project #
5P50AG005146-31
Application #
8662622
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
31
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Geiger, Joshua T; Ding, Jinhui; Crain, Barbara et al. (2016) Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies. Neurobiol Dis 94:55-62
Mata, Ignacio F; Leverenz, James B; Weintraub, Daniel et al. (2016) GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease. Mov Disord 31:95-102
Gross, Alden L; Mungas, Dan M; Leoutsakos, Jeannie-Marie S et al. (2016) Alzheimer's disease severity, objectively determined and measured. Alzheimers Dement (Amst) 4:159-168
Karch, Celeste M; Ezerskiy, Lubov A; Bertelsen, Sarah et al. (2016) Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One 11:e0148717
Forrester, Sarah N; Gallo, Joseph J; Smith, Gwenn S et al. (2016) Patterns of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Risk of Dementia. Am J Geriatr Psychiatry 24:117-25
Huo, Yuankai; Plassard, Andrew J; Carass, Aaron et al. (2016) Consistent cortical reconstruction and multi-atlas brain segmentation. Neuroimage 138:197-210
Gruenewald, Tara L; Tanner, Elizabeth K; Fried, Linda P et al. (2016) The Baltimore Experience Corps Trial: Enhancing Generativity via Intergenerational Activity Engagement in Later Life. J Gerontol B Psychol Sci Soc Sci 71:661-70
Oh, Esther S; Sieber, Frederick E; Leoutsakos, Jeannie-Marie et al. (2016) Sex Differences in Hip Fracture Surgery: Preoperative Risk Factors for Delirium and Postoperative Outcomes. J Am Geriatr Soc 64:1616-21
Yesavage, Jerome A; Taylor, Joy L; Friedman, Leah et al. (2016) Principal components analysis of agitation outcomes in Alzheimer's disease. J Psychiatr Res 79:4-7
McCutcheon, Sarah T; Han, Dingfen; Troncoso, Juan et al. (2016) Clinicopathological correlates of depression in early Alzheimer's disease in the NACC. Int J Geriatr Psychiatry 31:1301-1311

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