Core B: Clinical recruits, assesses, and follows all participants in the ADRC Cohort. It uses well-established informant-based clinical and psychometric instruments (including the Uniform Data Set) at entry and annually thereafter to obtain clinical, cognitive, behavioral, and neurological data to carefully characterize each participant as to the presence or absence of dementia and, when present, its severity and etiology. The Core has successfully provided participants, tissue, and data to all requesting Cores and Projects since its inception in 1985 and will continue to do so in the next 5-year funding period. On a daily basis, the Core interacts directly or indirectly with every facet of the ADRC. The Core's Specific Aims in the proposed funding period are: 1. Maintain an active longitudinal Cohort of ~ 300 participants, cognitively normal and with DAT, of individuals 65 years or more by annually enrolling 30 new participants to replenish attritional loss and to serve Projects 1 and 3 of this competing renewal application. 2. Ensure that Cohort participants contribute to the imaging, biofluid, and DNA (Core F: Genetics) protocols of the ADRC and its affiliated grants and obtain autopsies in deceased participants for Core D: Neuropathology. 3. Support the Core's African American Outreach Satellite. 4. Coordinate with Core C: Data Management and Statistics to integrate data procedures and respond to data sharing initiatives. 5. Coordinate the Core A: Administration to maintain the ADRC's contributions to multicenter collaborative studies, including the National Alzheimer's Coordinating Center. 6. Interact cooperatively with Core E: Education and Information Transfer and its Rural Education and Outreach Satellite to further the educational, training, and outreach goals of the ADRC.

Public Health Relevance

The ADRC Clinical Core maintains a cohort of longitudinally studied, well-characterized individuals with DAT and cognitively normal control individuals is required to investigate the critical relationships between healthy brain aging and Alzheimer's disease (AD). The WU ADRC Clinical Core has focused on the early detection of DAT in comparison with nondemented aging. The WU ADRC has developed clinical instruments, research findings, and concepts that have influenced the field.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Saint Louis
United States
Zip Code
Su, Yi; Blazey, Tyler M; Snyder, Abraham Z et al. (2015) Partial volume correction in quantitative amyloid imaging. Neuroimage 107:55-64
Shim, Yong Soo; Yang, Dong-Won; Roe, Catherine M et al. (2015) Pathological correlates of white matter hyperintensities on magnetic resonance imaging. Dement Geriatr Cogn Disord 39:92-104
Wang, Li-San; Naj, Adam C; Graham, Robert R et al. (2015) Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol 72:209-16
Karch, Celeste M; Goate, Alison M (2015) Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry 77:43-51
Ghoshal, Nupur; Perry, Arie; McKeel, Daniel et al. (2015) Variably Protease-sensitive Prionopathy in an Apparent Cognitively Normal 93-Year-Old. Alzheimer Dis Assoc Disord 29:173-6
Hurth, Kyle; Tarawneh, Rawan; Ghoshal, Nupur et al. (2015) Whipple's disease masquerades as dementia with Lewy bodies. Alzheimer Dis Assoc Disord 29:85-9
Aschenbrenner, Andrew J; Balota, David A; Tse, Chi-Shing et al. (2015) Alzheimer disease biomarkers, attentional control, and semantic memory retrieval: Synergistic and mediational effects of biomarkers on a sensitive cognitive measure in non-demented older adults. Neuropsychology 29:368-81
Benitez, Bruno A; Jin, Sheng Chih; Guerreiro, Rita et al. (2014) Missense variant in TREML2 protects against Alzheimer's disease. Neurobiol Aging 35:1510.e19-26
Dobrowolska, Justyna A; Kasten, Tom; Huang, Yafei et al. (2014) Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system. PLoS One 9:e89998
Hetland, Amanda J; Carr, David B; Wallendorf, Michael J et al. (2014) Potentially driver-impairing (PDI) medication use in medically impaired adults referred for driving evaluation. Ann Pharmacother 48:476-82

Showing the most recent 10 out of 427 publications