We will conduct five studies during the course of the requested funding. In Study I we will determine whether, when AD is combined with depression, tasks that require effortful processing are performed more poorly than tasks that require non-effortful processing. Study II investigates the validity of the CERAD Behavior Scale for Dementia, a newly developed scale designed to characterize non-cognitive behavioral features in AD. Studies III and IV will investigate the effects of personal and/or family history of psychopathology on current cognitive and non-cognitive behavioral features in AD patients. In study V, we will investigate the determination of stage of illness and psychopathological features of the deceased in cases which the diagnosis of Alzheimer's disease has been neuropathologically determined. The studies included in this project were originally proposed in a competitive supplement to our National Institute of Aging ADRC. In July of 1992 we received word that the supplement had been funded, effective June 1, 1 992. In the present proposal, we describe the work already begun on these studies and review revisions made in the studies to take into account the feedback received during the previous review. The studies are made possible by the availability of careful standardized assessments of current and past personal psychopathology and family history of psychopathology. They integrate data collected by the neuropsychology, psychopathology, and neuropathology components of the Alzheimer Center in order to test hypotheses and evaluate new procedures.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG008012-08
Application #
3726407
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Moon, Heehyul; Townsend, Aloen L; Whitlatch, Carol J et al. (2017) Quality of Life for Dementia Caregiving Dyads: Effects of Incongruent Perceptions of Everyday Care and Values. Gerontologist 57:657-666
Moon, Heehyul; Townsend, Aloen L; Dilworth-Anderson, Peggye et al. (2016) Predictors of Discrepancy Between Care Recipients With Mild-to-Moderate Dementia and Their Caregivers on Perceptions of the Care Recipients' Quality of Life. Am J Alzheimers Dis Other Demen 31:508-15
Nagpal, Neha; Heid, Allison R; Zarit, Steven H et al. (2015) Religiosity and quality of life: a dyadic perspective of individuals with dementia and their caregivers. Aging Ment Health 19:500-6
Merritt, Marcellus M; McCallum, T J (2013) Too much of a good thing?: Positive religious coping predicts worse diurnal salivary cortisol patterns for overwhelmed African American female dementia family caregivers. Am J Geriatr Psychiatry 21:46-56
Reamy, Allison M; Kim, Kyungmin; Zarit, Steven H et al. (2013) Values and preferences of individuals with dementia: perceptions of family caregivers over time. Gerontologist 53:293-302
Pirisinu, Laura; Nonno, Romolo; Esposito, Elena et al. (2013) Small ruminant nor98 prions share biochemical features with human gerstmann-sträussler-scheinker disease and variably protease-sensitive prionopathy. PLoS One 8:e66405
Xiao, Xiangzhu; Yuan, Jue; Haïk, Stéphane et al. (2013) Glycoform-selective prion formation in sporadic and familial forms of prion disease. PLoS One 8:e58786
Zarit, Steven H; Lee, Jeong E; Barrineau, Mary J et al. (2013) Fidelity and acceptability of an adaptive intervention for caregivers: an exploratory study. Aging Ment Health 17:197-206
Binoy Mathew, K V; Eapen, Charu; Kumar, P Senthil (2012) Reliability and Concurrent Validity of Dynamic Rotator Stability Test-A Cross Sectional study. Indian J Physiother Occup Ther 6:76-81
Reamy, Allison M; Kim, Kyungmin; Zarit, Steven H et al. (2011) Understanding discrepancy in perceptions of values: individuals with mild to moderate dementia and their family caregivers. Gerontologist 51:473-83

Showing the most recent 10 out of 227 publications