The ADRC Genetics Core (ADRC-GC) will provide a centralized resource for the organization and analysis of DNA and genetic data for the entire center, for project 3 in this funding cycle and for projects affiliated with the ADRC requiring the human genefic resources (e.g. NIA-LOAD Family study). Our overall goals are to facilitate the understanding of the associations between Alzheimer's disease or related neurodegenerative dementias and genetic variants, and to provide relevant information to investigators and patients and families. The ADRC-GC will be composed of four components already well integrated into the Columbia ADRC. 1) A DNA repository which includes data management to track biological sample inventories in coordinafion with the main ADRC database management core;2) A stafisfical genefics and genefic epidemiology group to facilitate research involving genefic variables;3) A genomics facility with Affymetrix, lllumina and Sequenom platforms that can handle various sized projects;4) Two board certified genefic counselors with expertise in neurodegenerative disorders available to help clinicians and families. The ADRC-GC will coordinate the research efforts of each of these sections, such that the resources from each section are optimally used to best address scientific questions..
The most significant risk factor for late-onset Alzheimer's disease (LOAD) is a family history of dementia. The years of collecting high risk families and large samples of cases and controls are now beginning to pay off showing the multiple genes are potentially involved in LOAD risk. Further these genes may interact with environmental or health factors. This core is poised to provide the need support to address these questions.
|Burke, Shanna L; O'Driscoll, Janice; Alcide, Amary et al. (2017) Moderating risk of Alzheimer's disease through the use of anxiolytic agents. Int J Geriatr Psychiatry 32:1312-1321|
|Sano, Mary; Zhu, Carolyn W; Grossman, Hillel et al. (2017) Longitudinal Cognitive Profiles in Diabetes: Results From the National Alzheimer's Coordinating Center's Uniform Data. J Am Geriatr Soc 65:2198-2204|
|Tripodis, Yorghos; Alosco, Michael L; Zirogiannis, Nikolaos et al. (2017) The Effect of Traumatic Brain Injury History with Loss of Consciousness on Rate of Cognitive Decline Among Older Adults with Normal Cognition and Alzheimer's Disease Dementia. J Alzheimers Dis 59:251-263|
|Brenowitz, Willa D; Hubbard, Rebecca A; Keene, C Dirk et al. (2017) Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement 13:654-662|
|Aguilar, Jenny I; Dunn, Matthew; Mingote, Susana et al. (2017) Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT. Neuron 95:1074-1088.e7|
|Jutkowitz, Eric; Kane, Robert L; Gaugler, Joseph E et al. (2017) Societal and Family Lifetime Cost of Dementia: Implications for Policy. J Am Geriatr Soc 65:2169-2175|
|Moheb, Negar; Mendez, Mario F; Kremen, Sarah A et al. (2017) Executive Dysfunction and Behavioral Symptoms Are Associated with Deficits in Instrumental Activities of Daily Living in Frontotemporal Dementia. Dement Geriatr Cogn Disord 43:89-99|
|Small, Scott A; Simoes-Spassov, Sabrina; Mayeux, Richard et al. (2017) Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease. Trends Neurosci 40:592-602|
|Monsell, Sarah E; Mock, Charles; Fardo, David W et al. (2017) Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology. Alzheimer Dis Assoc Disord 31:232-238|
|Montgomery, Valencia; Harris, Katie; Stabler, Anthony et al. (2017) Effects of Delay Duration on the WMS Logical Memory Performance of Older Adults with Probable Alzheimer's Disease, Probable Vascular Dementia, and Normal Cognition. Arch Clin Neuropsychol 32:375-380|
Showing the most recent 10 out of 587 publications