- DATA MANAGEMENT AND STATISTICAL CORE The Data Management and Statistical Core will provide database and statistical support and collaboration to all Mayo Alzheimer's Disease Research Center Cores and Projects. The members of the Core bring expertise in the development, implementation and management of relational databases and in the statistical methods needed for the projects. The Data Core will 1) maintain and optimize a relational database housing the longitudinal clinical and neuropsychometric data gathered by the Projects and Cores of the Mayo ADRC and 2) provide database support and biostatistical consulting support to the Projects and Cores of the Mayo ADRC. The Data Core plays a key role in carrying out the research themes of the Mayo ADRC, focusing on the data management and data analysis components of the research effort. As part of this effort, the Data Core is actively involved in the recruitment and retention of study participants, the incorporation of participant data into electronic data repositories, the exchange of participant samples and data within the Mayo ADRC and among other research groups, including the National Alzheimer's Coordinating Center (NACC), and in the analysis and of publication of research data. The Data Management and Statistical Core is essential to the proper functioning of the Mayo ADRC. The database systems of the Core are essential to activities including tracking participants'status for longitudinal follow-up, accurately storing and accessing data for research projects, appropriately uploading Uniform Data Set (UDS) data to NACC, and extracting data for the use of researchers in the conduct of their active investigations. The statistical expertise of the Core is of similar importance to the Mayo ADRC, as it is critical to the preparation of data for analysis, the design of analytical plans for specific research questions, the appropriate analysis of research data, and the final interpretation of the research findings. The Data Management and Statistical Core aims to collaborate in the advancement of scientific knowledge of Alzheimer's disease and related dementias through the resources which it provides to the Mayo ADRC.

Public Health Relevance

- DATA MANAGEMENT AND STATISTICAL CORE The Data Management and Statistical Core maintains the databases which store the data gathered at the Mayo ADRC, and interacts closely with the National Alzheimer's Coordinating Center (NACC) to make this data available to researchers across the country. Additionally, the Data Core provides database and analytical support to the Projects and Cores of the Mayo ADRC in order to answer questions aimed at advancing our understanding of the early features of Alzheimer's disease and of other AD-related dementias.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mayo Clinic, Rochester
United States
Zip Code
Tosto, Giuseppe; Bird, Thomas D; Bennett, David A et al. (2016) The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease. JAMA Neurol 73:1231-1237
Karch, Celeste M; Ezerskiy, Lubov A; Bertelsen, Sarah et al. (2016) Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One 11:e0148717
Ma, Li; Allen, Mariet; Sakae, Nobutaka et al. (2016) Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains. Mol Neurodegener 11:72
Kantarci, Kejal; Lowe, Val J; Lesnick, Timothy G et al. (2016) Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition. J Alzheimers Dis 53:547-56
Zheng, Honghua; Liu, Chia-Chen; Atagi, Yuka et al. (2016) Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiol Aging 42:132-41
Staubo, Sara C; Aakre, Jeremiah A; Vemuri, Prashanthi et al. (2016) Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness. Alzheimers Dement :
Labbé, Catherine; Heckman, Michael G; Lorenzo-Betancor, Oswaldo et al. (2016) MAPT haplotype diversity in multiple system atrophy. Parkinsonism Relat Disord 30:40-5
McCutcheon, Sarah T; Han, Dingfen; Troncoso, Juan et al. (2016) Clinicopathological correlates of depression in early Alzheimer's disease in the NACC. Int J Geriatr Psychiatry 31:1301-1311
Forrester, Sarah N; Gallo, Joseph J; Smith, Gwenn S et al. (2016) Patterns of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Risk of Dementia. Am J Geriatr Psychiatry 24:117-25
Day, Gregory S; Musiek, Erik S; Roe, Catherine M et al. (2016) Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. JAMA Neurol 73:1125-32

Showing the most recent 10 out of 813 publications