The Clinical Core of the UAB Alzheimer's Disease Research Center will provide to UAB investigators a cohort of subjects with mild and moderate AD, as well as age matched controls (emphasis on African-Americans), diagnosed by standard criteria. While the Clinical Core will be a University wide resource, our initial focus will be supporting the companion clinical studies included in this proposal. These studies will evaluate the important clinical, functional, and personal consequences of this grave illness: the competence to operate an automobile, the competence to manage one's financial affairs, and the utility of telephone based interventions for caregivers of demented patients. Our demonstrated ability to recruit from minority populations and our fortunate position as the only potential NIA ADRC in our state provides us the opportunity to secure a sizable diverse population for recruitment and make available these specialized services to an otherwise under-served area. In addition, this Core will handle all data services, including submission to the ADRC-combined data base, and will handle all autopsy procedures until the actual time of autopsy.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG016582-01S1
Application #
6217077
Study Section
Project Start
1999-08-15
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Lassen-Greene, Caroline L; Steward, Kayla; Okonkwo, Ozioma et al. (2017) Mild Cognitive Impairment and Changes in Everyday Function Over Time: The Importance of Evaluating Both Speed and Accuracy. J Geriatr Psychiatry Neurol 30:220-227
Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384
Niccolai, Lindsay M; Triebel, Kristen L; Gerstenecker, Adam et al. (2017) Neurocognitive Predictors of Declining Financial Capacity in Persons with Mild Cognitive Impairment. Clin Gerontol 40:14-23
Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738
Karch, Celeste M; Ezerskiy, Lubov A; Bertelsen, Sarah et al. (2016) Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One 11:e0148717
Mez, Jesse; Mukherjee, Shubhabrata; Thornton, Timothy et al. (2016) The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiol Aging 41:115-121
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-200.e20
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150
Jun, G; Ibrahim-Verbaas, C A; Vronskaya, M et al. (2016) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry 21:108-17
Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43

Showing the most recent 10 out of 114 publications