The Emory Alzheimer's Disease Research Center (ADRC) coordinates growth and integrates basic research and clinical science activities relevant to Alzheimer's disease and other related neurodegenerative disorders. Our Team consists of a large multi-disciplinary group of faculty and staff committed to collaborations and the success of the ADRC. The ADRC Administrative Core plays the central role in coordinating interactions among the ADRC Cores and Research Projects and other centers and programs to leverage opportunities and achieve its goals. In our initial funding period we have established and documented standard operating procedures for each of the Cores, provided opportunities for regular communications and interactions, secured strong financial underpinnings with additional generous support from the institution and community, facilitated recruitment and development of junior faculty and minorities, and attracted new faculty to the field of AD research at Emory. The following specific aims will be pursued to achieve the Emory ADRC Administrative Core's mission: 1) To actively coordinate, integrate, and plan for all ADRC activities and research interactions and to oversee the progress to ensure optimal utilization, leveraging, and management of resources;2) To solicit, review, develop and implement Pilot and Research Projects;3) To enhance AD research, clinical care, and education by maximizing opportunities for interaction with other ADCs and AD investigators, as well as other local, regional, national, and international institutions, agencies, including NIA, and industries, and timely submission of data sets to the National Alzheimer's Coordinating Center;4) To cultivate an environment that promotes the highest standards for ethics in clinical care and research, and compliance with human subjects, animal welfare, fiscal policies, and scientific integrity. Through these aims we will continue building the relationships and connections necessary to advance efforts towards diagnosing and treating patients suffering from AD and other related neurodegnerative diseases.
The state of Georgia's population is aging rapidly and by 2030, one in five Georgians will be over 60. Given that advancing age is a primary risk factor in developing Alzheimer's disease, this population shift will pose a major public health problem in managing the consequences ofthe disease. The proposed work will provide the infrastructure necessary to support the efforts of the Emory ADRC to better understand the causes and hence accelerate improvements in care of individuals with Alzheimer's disease.
|Matveev, Sergey V; Spielmann, Hans Peter; Metts, Brittney M et al. (2014) A distinct subfraction of A? is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brain. J Neurochem 131:356-68|
|England, Heather B; Gillis, M Meredith; Hampstead, Benjamin M (2014) RBANS memory indices are related to medial temporal lobe volumetrics in healthy older adults and those with mild cognitive impairment. Arch Clin Neuropsychol 29:322-8|
|Chopra, Pankaj; Papale, Ligia A; White, Andrew T J et al. (2014) Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice. BMC Genomics 15:131|
|Lohr, Kelly M; Bernstein, Alison I; Stout, Kristen A et al. (2014) Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo. Proc Natl Acad Sci U S A 111:9977-82|
|Goldstein, Felicia C; Ashley, Angela V; Miller, Eric et al. (2014) Validity of the montreal cognitive assessment as a screen for mild cognitive impairment and dementia in African Americans. J Geriatr Psychiatry Neurol 27:199-203|
|Kummer, Markus P; Hammerschmidt, Thea; Martinez, Ana et al. (2014) Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. J Neurosci 34:8845-54|
|Göttle, Martin; Prudente, Cecilia N; Fu, Rong et al. (2014) Loss of dopamine phenotype among midbrain neurons in Lesch-Nyhan disease. Ann Neurol 76:95-107|
|Richardson, Jason R; Roy, Ananya; Shalat, Stuart L et al. (2014) Elevated serum pesticide levels and risk for Alzheimer disease. JAMA Neurol 71:284-90|
|Feldman, Eva L; Boulis, Nicholas M; Hur, Junguk et al. (2014) Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: phase 1 trial outcomes. Ann Neurol 75:363-73|
|Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606|
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