The mission of the Wisconsin Alzheimer's Disease Research Center (ADRC) Data Management and Biostatistics Core (Core C) is to promote excellence by providing outstanding data management, biomedical computing, and biostatistical support to Wisconsin ADRC investigators and affiliates. To accomplish this objective, Core C has the following specific aims:
Specific Aim 1 : To provide and maintain quality protocol and data management for projects affiliated with the Wisconsin ADRC;
Specific Aim 2 : To provide a biomedical computing infrastructure and services for projects affiliated with the Wisconsin ADRC;
Specific Aim 3 : To provide comprehensive statistical support (including study design, implementation, data analysis, and methodology development) to all projects associated with the Wisconsin ADRC;
Specific Aim 4 : To work with the NACC to create a smooth and efficient exchange of data and to collaborate with other ADRCs, ADCCs, and AD researchers;
Specific Aim 5 : To interface effectively with each of the other Wisconsin ADRC Cores to provide comprehensive, high-quality support to achieve the overall mission of the ADRC. The proposed specific aims will utilize and solidify existing resources to ensure an effective ADRC that will support cutting-edge clinical, basic, and translational research on a cohort at risk for AD (i.e., WRAP), as well as those with MCI, AD and related neurodegenerative disorders. These resources include extensive existing collaborations, financial commitments, data sources and acknowledged excellence in data management, an existing state-wide network, advanced informatics capabilities, and acknowledged expertise in biostatistics and informatics

Public Health Relevance

The Data Management and Biostatistics Core will provide critical support for the Wisconsin ADRC to accomplish its objectives targeting one of the most common and devastating neurodegenerative illnesses known to afflict humans. Given the projected exponential increase in the number of Americans likely to be affected by AD, it is pivotal that novel treatment and prevention strategies be identified. The Wisconsin ADRC will help accomplish this national priority.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG033514-05
Application #
8449657
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2013
Total Cost
$180,449
Indirect Cost
$59,052
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Clark, Lindsay R; Koscik, Rebecca L; Allison, Samantha L et al. (2018) Hypertension and obesity moderate the relationship between ?-amyloid and cognitive decline in midlife. Alzheimers Dement :
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Martin, Stephen A; Souder, Dylan C; Miller, Karl N et al. (2018) GSK3? Regulates Brain Energy Metabolism. Cell Rep 23:1922-1931.e4
Swanson, Ashley; Wolf, Tovah; Sitzmann, Alli et al. (2018) Neuroinflammation in Alzheimer's disease: Pleiotropic roles for cytokines and neuronal pentraxins. Behav Brain Res 347:49-56
Gilmore-Bykovskyi, Andrea (2018) Commentary on Apathy as a Model for Investigating Behavioral and Psychological Symptoms in Dementia. J Am Geriatr Soc 66 Suppl 1:S13-S16
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Johnson, Sterling C; Koscik, Rebecca L; Jonaitis, Erin M et al. (2018) The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions. Alzheimers Dement (Amst) 10:130-142

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