The goal of the University of Iowa CORT is to develop new methods of forestalling post-traumatic osteoarthritis (PTOA) through a multi-disciplinary translational approach including basic science, bioengineering, imaging, and clinical research. The central theme is that joint injuries initiate a sequence of biologic events that lead to PTOA and that new treatments of joint injuries will minimize these deleterious events and promote joint healing.
The specific aims are to: 1) advance understanding of the pathogenesis of PTOA, 2) develop and refine reliable quantitative measures of severity of joint injuries, including measures of structural damage and biologic response to joint injury, and 3) apply the advances in understanding of the pathogenesis of PTOA and assessment of joint injury to new methods of forestalling PTOA. The four CORT projects are: 1. Cartilage Extracellular Matrix Fragments and Trauma-Induced Chondrolysis, an in vitro study that will identify pathways responsible for propagation of cell damage following injury;2. Acute versus Chronic Mechanical Damage in the Etiology of PTOA, an experimental study that will define the role of loading of injured joints in causing OA, and new methods for preventing OA in injured joints;3. Validation and Application of MRI Biomarkers in Assessing Articular Cartilage Health, a clinical and experimental study of non-fracture cartilage injury that will help define the ability of non-invasive measures to assess the severity of cartilage damage, that will identify which synovial fluid markers of acute joint injury reflect that damage, and that will test the hypothesis that decreased loading accelerates restoration of injured joint surfaces;and 4. Quantifying Injury Severity to Assess the Risk for Post-Traumatic OA, a clinical study of intra-articular fractures that will examine the hypothesis that new quantitative measures of the severity of structural joint injury predict clinical outcomes. This project also will conduct a multi-center study of the severity of joint injury, in preparation for clinical trials of molecular interventions to minimize the risk of OA following joint injury. The four projects will be supported by an administrative-biostatistics core, a biomechanics-imaging core, and a tissue and experimental modeling core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
2P50AR055533-06
Application #
8341017
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Program Officer
Lester, Gayle E
Project Start
2007-09-10
Project End
2017-06-30
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
6
Fiscal Year
2012
Total Cost
$1,437,369
Indirect Cost
$460,163
Name
University of Iowa
Department
Orthopedics
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Ding, Lei; Buckwalter, Joseph A; Martin, James A (2017) DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017:2642549
Dibbern, Kevin; Kempton, Laurence B; Higgins, Thomas F et al. (2017) Fractures of the tibial plateau involve similar energies as the tibial pilon but greater articular surface involvement. J Orthop Res 35:618-624
Segal, Neil A; Bergin, John; Kern, Andrew et al. (2017) Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner. Skeletal Radiol 46:217-222
Martin, James A; Anderson, Donald D; Goetz, Jessica E et al. (2017) Complementary models reveal cellular responses to contact stresses that contribute to post-traumatic osteoarthritis. J Orthop Res 35:515-523
Ayati, Bruce P; Kapitanov, Georgi I; Coleman, Mitchell C et al. (2017) Mathematics as a conduit for translational research in post-traumatic osteoarthritis. J Orthop Res 35:566-572
Goetz, Jessica E; Coleman, Mitchell C; Fredericks, Douglas C et al. (2017) Time-dependent loss of mitochondrial function precedes progressive histologic cartilage degeneration in a rabbit meniscal destabilization model. J Orthop Res 35:590-599
Seol, Dongrim; Zhou, Cheng; Brouillette, Marc J et al. (2017) Characteristics of meniscus progenitor cells migrated from injured meniscus. J Orthop Res 35:1966-1972
Pedersen, Douglas R; El-Khoury, Georges Y; Thedens, Dan R et al. (2017) Bone contusion progression from traumatic knee injury: association of rate of contusion resolution with injury severity. Open Access J Sports Med 8:9-15
Coleman, Mitchell C; Brouillette, Marc J; Andresen, Nicholas S et al. (2017) Differential Effects of Superoxide Dismutase Mimetics after Mechanical Overload of Articular Cartilage. Antioxidants (Basel) 6:
Heckelsmiller, David J; James Rudert, M; Baer, Thomas E et al. (2017) Changes in Joint Contact Mechanics in a Large Quadrupedal Animal Model After Partial Meniscectomy and a Focal Cartilage Injury. J Biomech Eng 139:

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