Recently, magnetic resonance (MR) T2 and T1p relaxation time measurements have emerged as potential markers for early biochemical cartilage degeneration, and thus may be important when examining the pathogenesis of OA. Additionally, changes in kinematics, kinetics, spatiotemporal gait characteristics and functional activities have been reported in patients with early hip OA. The proposed study aims to investigate biochemical differences that may be seen in mild and moderate radiographic hip OA using MRI, exploring their relation to kinematics and function. It also aims to explore cartilage degeneration and progression of hip OA longitudinally, and establish the relationship between changes in composition and the development of morphological lesions. Our central hypothesis is that image-based measures of hip cartilage biochemical composition differs between controls and patients with hip OA, and are related to cartilage morphology, hip biomechanics, pain, function and severity of disease. To test this hypothesis, this study will 1) characterize hip cartilage composition (measured by MRI Tip and T2 relaxation times) in patients with hip OA, compared to controls, 2) determine the cross-sectional and longitudinal relationship between hip cartilage composition and morphology, and 3) determine whether hip cartilage composition is related to patient function (kinematics, kinetics, spatiotemporal gait characteristics, functional tests) and pain (WOMAC), both cross-sectionally and longitudinally. The results of the proposed study will help determine whether early biochemical degeneration in cartilage, as quantified by T2 and T1p mapping parameters, is associated with the progression of hip OA and is related to hip OA outcomes such as detriments in patient function. By evaluating the interrelationship between MR markers of compositional changes in OA and movement patterns during functional tasks, this study provides an essential link between tissue structure and function in the hip joint. In this proposal, an interdisciplinary team extends their extensive prior work in the knee, and to elucidate the complex interactions of abnormal movement patterns, cartilage biochemical and morphologic degeneration during the progression and outcomes of hip OA.
Osteoarthritis (OA) is the second most common cause of permanent disability among subjects over the age of fifty. Given limited treatment options preventive efforts are of central importance to preserve joint health. This, however, requires sensitive biomarkers to predict the risk of OA and monitor its progression. The overall impact of this project will be to investigate the role of the imaging biomarkers in normal individuals, those with hip OA in the evolution and progression of the disease.
|Joseph, G B; Nevitt, M C; McCulloch, C E et al. (2018) Associations between molecular biomarkers and MR-based cartilage composition and knee joint morphology: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 26:1070-1077|
|Amano, Keiko; Huebner, Janet L; Stabler, Thomas V et al. (2018) Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery. Am J Sports Med 46:890-899|
|Samaan, Michael A; Pedoia, Valentina; Zhang, Alan L et al. (2018) A novel mr-based method for detection of cartilage delamination in femoroacetabular impingement patients. J Orthop Res 36:971-978|
|Hofmann, Felix C; Neumann, Jan; Heilmeier, Ursula et al. (2018) Conservatively treated knee injury is associated with knee cartilage matrix degeneration measured with MRI-based T2 relaxation times: data from the osteoarthritis initiative. Skeletal Radiol 47:93-106|
|Pedoia, Valentina; Samaan, Michael A; Inamdar, Gaurav et al. (2018) Study of the interactions between proximal femur 3d bone shape, cartilage health, and biomechanics in patients with hip Osteoarthritis. J Orthop Res 36:330-341|
|Teng, Hsiang-Ling; Pedoia, Valentina; Link, Thomas M et al. (2018) Local associations between knee cartilage T1? and T2 relaxation times and patellofemoral joint stress during walking: A voxel-based relaxometry analysis. Knee 25:406-416|
|Pedoia, Valentina; Haefeli, Jenny; Morioka, Kazuhito et al. (2018) MRI and biomechanics multidimensional data analysis reveals R2 -R1? as an early predictor of cartilage lesion progression in knee osteoarthritis. J Magn Reson Imaging 47:78-90|
|Bolcos, Paul O; Mononen, Mika E; Mohammadi, Ali et al. (2018) Comparison between kinetic and kinetic-kinematic driven knee joint finite element models. Sci Rep 8:17351|
|Lansdown, Drew; Ma, Chunbong Benjamin (2018) The Influence of Tibial and Femoral Bone Morphology on Knee Kinematics in the Anterior Cruciate Ligament Injured Knee. Clin Sports Med 37:127-136|
|Schwaiger, Benedikt J; Mbapte Wamba, John; Gersing, Alexandra S et al. (2018) Hyperintense signal alteration in the suprapatellar fat pad on MRI is associated with degeneration of the patellofemoral joint over 48 months: data from the Osteoarthritis Initiative. Skeletal Radiol 47:329-339|
Showing the most recent 10 out of 150 publications