The major objective of the Administrative Core is to focus the efforts of the UAB CORT in Gout and Hyperuricemia on four specific research projects. Our theme is 'Gout and Hyperuricemia: from Bench to Bedside to Backyard'. We propose a multi-disciplinary approach to type 1 (T1) and type 2 (T2) translational research projects that present significant opportunities for advancement of l<nowledge in four major research areas relevant to gout and hyperuricemia: 1) Genetics of gout, 2) Hyperuricemia and cardiovascular outcomes, 3) Evidence implementation, effectiveness, and safety of gout therapies in large populations. The four projects are further united by a subtheme of racial/ethnic disparities in gout and hyperuricemia. The overall goal for our UAB CORT is to improve the healthcare of patients with gout and hyperuricemia by applying scientifically rigorous, state-of-the-art methodology to clinically important questions in translational research. The specific objectives of the UAB CORT's Administrative Core are to assure the CORT has the organizational oversight and institutional resources to: 1. Conduct outstanding, innovative research projects drawing on the unique strengths of the UAB Comprehensive Arthritis Musculoskeletal, and Autoimmunity Center (CAMAC), along with other relevant University-wide Interdisciplinary Research Centers and academic units (e.g. the UAB Division of Clinical Immunology and Rheumatology) using state-of-the-art tools from genetics and pharmacogenetics, biostatistics, epidemiology, clinical trials design, and outcomes research. 2. Foster the development of Development and Feasibility projects and the development and application of new evaluative, analytic, and translational methods to research in gout and hyperuricemia; and, 3. Through an enrichment program, promote the training of clinical investigators in the most current methods of translational research applicable to gout and hyperuricemia. The Administrative Core will coordinate the UAB CORT's activities while facilitating interactions and collaborations, promoting scientific development, performing continuous evaluation of ongoing UAB CORT programs, and setting the strategic agenda for the UAB CORT. A major responsibility of the Administrative Core is to focus the resources of the Institution on the CORT, its investigators, and its specific research projects. The strong research resources, robust institutional commitment, and an experienced, multi- disciplinary, highly energetic and focused team of investigators predict a high likelihood of success.
Gout and high serum urate levels are common. Our CORT in Gout; aimed at improving the care of patients with gout; will be overseen by an Administrative core. This Core will assure that scientifically rigorous; state- of-the-art methodology is applied to clinically important questions in translational research.
|Taylor, William J; Redden, David; Dalbeth, Nicola et al. (2014) Application of the OMERACT filter to measures of core outcome domains in recent clinical studies of acute gout. J Rheumatol 41:574-80|
|Kirwan, John R; Boers, Maarten; Hewlett, Sarah et al. (2014) Updating the OMERACT filter: core areas as a basis for defining core outcome sets. J Rheumatol 41:994-9|
|Stamp, Lisa K; Merriman, Tony R; Barclay, Murray L et al. (2014) Impaired response or insufficient dosage? Examining the potential causes of "inadequate response" to allopurinol in the treatment of gout. Semin Arthritis Rheum 44:170-4|
|(2014) Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384:1005-70|
|Singh, Jasvinder A; Lewallen, David G (2014) Time trends in the characteristics of patients undergoing primary total knee arthroplasty. Arthritis Care Res (Hoboken) 66:897-906|
|Dalbeth, Nicola; Zhong, Cathy S; Grainger, Rebecca et al. (2014) Outcome measures in acute gout: a systematic literature review. J Rheumatol 41:558-68|
|Sattui, Sebastian E; Singh, Jasvinder A; Gaffo, Angelo L (2014) Comorbidities in patients with crystal diseases and hyperuricemia. Rheum Dis Clin North Am 40:251-78|
|Singh, Jasvinder A (2014) Facilitators and barriers to adherence to urate-lowering therapy in African-Americans with gout: a qualitative study. Arthritis Res Ther 16:R82|
|Singh, Jasvinder A (2014) The impact of gout on patient's lives: a study of African-American and Caucasian men and women with gout. Arthritis Res Ther 16:R132|
|Singh, Jasvinder A; Taylor, William J; Dalbeth, Nicola et al. (2014) OMERACT endorsement of measures of outcome for studies of acute gout. J Rheumatol 41:569-73|
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