The major objective of the Administrative Core is to focus the efforts of the UAB CORT in Gout and Hyperuricemia on four specific research projects. Our theme is 'Gout and Hyperuricemia: from Bench to Bedside to Backyard'. We propose a multi-disciplinary approach to type 1 (T1) and type 2 (T2) translational research projects that present significant opportunities for advancement of l<nowledge in four major research areas relevant to gout and hyperuricemia: 1) Genetics of gout, 2) Hyperuricemia and cardiovascular outcomes, 3) Evidence implementation, effectiveness, and safety of gout therapies in large populations. The four projects are further united by a subtheme of racial/ethnic disparities in gout and hyperuricemia. The overall goal for our UAB CORT is to improve the healthcare of patients with gout and hyperuricemia by applying scientifically rigorous, state-of-the-art methodology to clinically important questions in translational research. The specific objectives of the UAB CORT's Administrative Core are to assure the CORT has the organizational oversight and institutional resources to: 1. Conduct outstanding, innovative research projects drawing on the unique strengths of the UAB Comprehensive Arthritis Musculoskeletal, and Autoimmunity Center (CAMAC), along with other relevant University-wide Interdisciplinary Research Centers and academic units (e.g. the UAB Division of Clinical Immunology and Rheumatology) using state-of-the-art tools from genetics and pharmacogenetics, biostatistics, epidemiology, clinical trials design, and outcomes research. 2. Foster the development of Development and Feasibility projects and the development and application of new evaluative, analytic, and translational methods to research in gout and hyperuricemia; and, 3. Through an enrichment program, promote the training of clinical investigators in the most current methods of translational research applicable to gout and hyperuricemia. The Administrative Core will coordinate the UAB CORT's activities while facilitating interactions and collaborations, promoting scientific development, performing continuous evaluation of ongoing UAB CORT programs, and setting the strategic agenda for the UAB CORT. A major responsibility of the Administrative Core is to focus the resources of the Institution on the CORT, its investigators, and its specific research projects. The strong research resources, robust institutional commitment, and an experienced, multi- disciplinary, highly energetic and focused team of investigators predict a high likelihood of success.

Public Health Relevance

Gout and high serum urate levels are common. Our CORT in Gout; aimed at improving the care of patients with gout; will be overseen by an Administrative core. This Core will assure that scientifically rigorous; state- of-the-art methodology is applied to clinically important questions in translational research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR060772-03
Application #
8731621
Study Section
Special Emphasis Panel (ZAR1-KM)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
Fiscal Year
2014
Total Cost
$176,062
Indirect Cost
$62,635
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Singh, Jasvinder A; Ramachandaran, Rekha (2016) Does rural residence impact total ankle arthroplasty utilization and outcomes? Clin Rheumatol 35:381-6
Saddekni, Michael B; Saag, Kenneth G; Dudenbostel, Tanja et al. (2016) The effects of urate lowering therapy on inflammation, endothelial function, and blood pressure (SURPHER) study design and rationale. Contemp Clin Trials 50:238-44
Coburn, Brian W; Cheetham, T Craig; Rashid, Nazia et al. (2016) Rationale and design of the randomized evaluation of an Ambulatory Care Pharmacist-Led Intervention to Optimize Urate Lowering Pathways (RAmP-UP) Study. Contemp Clin Trials 50:106-15
Singh, Jasvinder A; Yu, Shaohua (2016) Gout-related inpatient utilization: a study of predictors of outcomes and time trends. Arthritis Res Ther 18:57
Singh, Jasvinder A; Ramachandran, Rekha (2016) Time trends in total ankle arthroplasty in the USA: a study of the National Inpatient Sample. Clin Rheumatol 35:239-45
Reynolds, Richard J; Vazquez, Ana I; Srinivasasainagendra, Vinodh et al. (2016) Serum urate gene associations with incident gout, measured in the Framingham Heart Study, are modified by renal disease and not by body mass index. Rheumatol Int 36:263-70
Singh, Jasvinder A; Yu, Shaohua (2016) Utilization due to chronic obstructive pulmonary disease and its predictors: a study using the U.S. National Emergency Department Sample (NEDS). Respir Res 17:1
Singh, Jasvinder A; Yu, Shaohua (2016) Time Trends, Predictors, and Outcome of Emergency Department Use for Gout: A Nationwide US Study. J Rheumatol 43:1581-8
Singh, Jasvinder A; Qu, Haiyan; Yazdany, Jinoos et al. (2015) Barriers to Medication Decision Making in Women with Lupus Nephritis: A Formative Study using Nominal Group Technique. J Rheumatol 42:1616-23
Singh, Jasvinder A; Ramachandran, Rekha (2015) Does hospital volume predict outcomes and complications after total shoulder arthroplasty in the US? Arthritis Care Res (Hoboken) 67:885-90

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