The major objective of the Administrative Core is to focus the efforts of the UAB CORT in Gout and Hyperuricemia on four specific research projects. Our theme is 'Gout and Hyperuricemia: from Bench to Bedside to Backyard'. We propose a multi-disciplinary approach to type 1 (T1) and type 2 (T2) translational research projects that present significant opportunities for advancement of l<nowledge in four major research areas relevant to gout and hyperuricemia: 1) Genetics of gout, 2) Hyperuricemia and cardiovascular outcomes, 3) Evidence implementation, effectiveness, and safety of gout therapies in large populations. The four projects are further united by a subtheme of racial/ethnic disparities in gout and hyperuricemia. The overall goal for our UAB CORT is to improve the healthcare of patients with gout and hyperuricemia by applying scientifically rigorous, state-of-the-art methodology to clinically important questions in translational research. The specific objectives of the UAB CORT's Administrative Core are to assure the CORT has the organizational oversight and institutional resources to: 1. Conduct outstanding, innovative research projects drawing on the unique strengths of the UAB Comprehensive Arthritis Musculoskeletal, and Autoimmunity Center (CAMAC), along with other relevant University-wide Interdisciplinary Research Centers and academic units (e.g. the UAB Division of Clinical Immunology and Rheumatology) using state-of-the-art tools from genetics and pharmacogenetics, biostatistics, epidemiology, clinical trials design, and outcomes research. 2. Foster the development of Development and Feasibility projects and the development and application of new evaluative, analytic, and translational methods to research in gout and hyperuricemia; and, 3. Through an enrichment program, promote the training of clinical investigators in the most current methods of translational research applicable to gout and hyperuricemia. The Administrative Core will coordinate the UAB CORT's activities while facilitating interactions and collaborations, promoting scientific development, performing continuous evaluation of ongoing UAB CORT programs, and setting the strategic agenda for the UAB CORT. A major responsibility of the Administrative Core is to focus the resources of the Institution on the CORT, its investigators, and its specific research projects. The strong research resources, robust institutional commitment, and an experienced, multi- disciplinary, highly energetic and focused team of investigators predict a high likelihood of success.

Public Health Relevance

Gout and high serum urate levels are common. Our CORT in Gout; aimed at improving the care of patients with gout; will be overseen by an Administrative core. This Core will assure that scientifically rigorous; state- of-the-art methodology is applied to clinically important questions in translational research.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Specialized Center (P50)
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Special Emphasis Panel (ZAR1-KM)
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University of Alabama Birmingham
United States
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Singh, Jasvinder A; Hossain, Alomgir; Mudano, Amy S et al. (2017) Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis. Cochrane Database Syst Rev 5:CD012657
Singh, Jasvinder A; Hossain, Alomgir; Tanjong Ghogomu, Elizabeth et al. (2017) Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis. Cochrane Database Syst Rev 3:CD012591
Neogi, Tuhina; Mikuls, Ted R (2017) To Treat or Not to Treat (to Target) in Gout. Ann Intern Med 166:71-72
Singh, Jasvinder A; Yu, Shaohua (2016) Utilization due to chronic obstructive pulmonary disease and its predictors: a study using the U.S. National Emergency Department Sample (NEDS). Respir Res 17:1
Singh, Jasvinder A; Yu, Shaohua (2016) Time Trends, Predictors, and Outcome of Emergency Department Use for Gout: A Nationwide US Study. J Rheumatol 43:1581-8
Singh, Jasvinder A; Yu, Shaohua (2016) Gout-related inpatient utilization: a study of predictors of outcomes and time trends. Arthritis Res Ther 18:57
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Coburn, Brian W; Cheetham, T Craig; Rashid, Nazia et al. (2016) Rationale and design of the randomized evaluation of an Ambulatory Care Pharmacist-Led Intervention to Optimize Urate Lowering Pathways (RAmP-UP) Study. Contemp Clin Trials 50:106-15
Reynolds, Richard J; Vazquez, Ana I; Srinivasasainagendra, Vinodh et al. (2016) Serum urate gene associations with incident gout, measured in the Framingham Heart Study, are modified by renal disease and not by body mass index. Rheumatol Int 36:263-70
Singh, Jasvinder A; Ramachandran, Rekha (2016) Time trends in total ankle arthroplasty in the USA: a study of the National Inpatient Sample. Clin Rheumatol 35:239-45

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