Carpal tunnel syndrome (CTS) is the most frequently occurring peripheral nerve entrapment disorder (median nerve at the wrist) and is also one of the most prevalent modern-age upper limb musculoskeletal disorders. Despite its prevalence, the exact etiology and pathophysiology underlying CTS is unclear at this time.This project will address these gaps in knowledge and contribute to furthering our understanding of disease mechanism, and thereby improve the overall clinical care of patients with CTS by offering preventive measures or alternative therapeutic strategies. The proposed study is novel for the CTS field, and represents the largest natural history study incorporating the state-of-the-art high-resolution ultrasound (HRUS) and electrodiagnosis/electromyography (EDX) methodologies. We will follow a cohort of females and males with idiopathic CTS using a prospective natural history study design with 6 weeks of 'standard-of-care' conservative wrist splint treatment, and follow up for 12 months with the following aims.
Aim 1 : To determine and compare the baseline HRUS characteristics in females with and without idiopathic CTS (adjusted for age and BMI), and in males with and without idiopathic CTS (adjusted for age and BMI).
Aim 2 : To determine and compare by sex the ability of novel HRUS characteristics and patient-reported outcome measures in CTS to detect treatment effect changes between the pre- and post-treatment in men and women after 6 weeks of standard nocturnal neutral wrist splint treatment;and evaluate for correlation with other traditional measures of CTS severity and progression (as measured by hand diagram, sensibility testing, provocative maneuvers, and EDX parameters).
Aim 3 : To determine and compare the patient characteristics (age, sex, BMI, wrist anthropometrics, job-related risk factors), health-related quality of life measures, and clinical measures for CTS severity (physical measures, electrodiagnostic and sonographic parameters) in relation to short- and long-term outcomes in idiopathic CTS.

Public Health Relevance

Establishment of standardized high-resolution ultrasound methodologies and determination of test capabilities in the diagnosis and monitoring of carpal tunnel syndrome will have important impact not only in health care of individuals with carpal tunnel syndrome but will also have far-reaching implications of reduced healthcare cost to society and increased economic productivity.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Specialized Center (P50)
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Special Emphasis Panel (ZRG1)
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University of California Davis
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Zhong, Zhendong A; Kot, Alexander; Lay, Yu-An E et al. (2017) Sex-Dependent, Osteoblast Stage-Specific Effects of Progesterone Receptor on Bone Acquisition. J Bone Miner Res 32:1841-1852
Rogers, Tara S; Harrison, Stephanie; Swanson, Christine et al. (2017) Rest-activity circadian rhythms and bone mineral density in elderly men. Bone Rep 7:156-163
Kot, Alexander; Zhong, Zhendong A; Zhang, Hongliang et al. (2017) Sex dimorphic regulation of osteoprogenitor progesterone in bone stromal cells. J Mol Endocrinol 59:351-363
Zhang, Hongliang; Kot, Alexander; Lay, Yu-An E et al. (2017) Acceleration of Fracture Healing by Overexpression of Basic Fibroblast Growth Factor in the Mesenchymal Stromal Cells. Stem Cells Transl Med 6:1880-1893
Katzman, Wendy B; Huang, Mei-Hua; Kritz-Silverstein, Donna et al. (2017) Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Impaired Physical Function: The Rancho Bernardo Study. J Am Geriatr Soc 65:1476-1481
Wise, B L; Niu, J; Guermazi, A et al. (2017) Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease - data from the Osteoarthritis Initiat Osteoarthritis Cartilage 25:85-93
Tran, Tuan A; Williams, Lisa M; Bui, Donna et al. (2017) Prospective Pilot Study Comparing Pre- and Postsurgical CTSAQ and Neuro-QoL Questionnaire with Median Nerve High-Resolution Ultrasound Cross-Sectional Areas. J Hand Surg Am :
Rogers, Tara S; Blackwell, Terri L; Lane, Nancy E et al. (2017) Rest-activity patterns and falls and fractures in older men. Osteoporos Int 28:1313-1322
Manickam, Raj N; Mu, Yi; Kshirsagar, Abhijit V et al. (2017) Area-Level Poverty and Excess Hospital Readmission Ratios. Am J Med 130:e153-e155
Nielson, Carrie M; Wiedrick, Jack; Shen, Jian et al. (2017) Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics. J Bone Miner Res 32:1559-1567

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