This application is for a renewal of our Dietary Supplement Research Center focusing on Botanicals. Our Botanical Research Center is a collaborative effort between the Pennington Biomedical Research Center of the Louisiana State University (LSU) System and the Biotechnology Center for Agriculture and the Environment of Rutgers University. The theme of the Center is "Botanicals and Metabolic Syndrome". The "metabolic syndrome" defines a human condition whose major features consist of obesity, insulin resistance, development of Type 2 diabetes and accelerated cardiovascular disease. As the prevalence of metabolic syndrome is reaching epidemic proportions worldwide, metabolic syndrome has been, and will continue to be, one of the most important public health problems facing society. Our Botanical Research Center will consist of three (3) research projects, an Integrative Biology Core, a Botanical core and an Administrative core. Each of the research projects will evaluate specific botanicals and assess the effect on cellular mechanisms proposed to contribute to the pathophysiology and development of the metabolic syndrome. Project 1 investigators will conduct studies to evaluate mechanisms of action by which selected extracts of Artemisia sp. modulate insulin receptor signaling and insulin sensitivity in both animal and in early phase human studies. Project 2 investigators will focus on mechanisms by which selected Artemisia sp. extracts and Hypericum perforatum L. (St. John's Wort) effect adipocyte development, adipokines, and insulin action. Project 3 investigators will evaluate how Asclepias incarnata modulates central mechanisms controlling appetite and energy expenditure as a means to improve overall energy balance and weight. We propose to use cutting-edge technologies that include metabolomic profiling, proteomic assessments, and bioaccessibility determinations. Thus, the scientific goal of our Center is to provide a comprehensive evaluation of specific, compelling hypotheses about the molecular, cellular and physiological mechanisms by which botanicals can modulate the development of the underlying pathophysiologic mechanisms of, and attenuate the development to, metabolic syndrome.

Public Health Relevance

Given the complications for metabolic syndrome, it is imperative that we implement effective strategies to improve the underlying pathophysiologic factors contributing to the condition. Our comprehensive study of botanicals and their effects to modulate pathologic processes leading to the development of the metabolic syndrome has great potential for being translated into practical benefits for human health.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
5P50AT002776-09
Application #
8543509
Study Section
Special Emphasis Panel (ZAT1-SM (19))
Program Officer
Hopp, Craig
Project Start
2005-04-01
Project End
2015-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
9
Fiscal Year
2013
Total Cost
$1,588,979
Indirect Cost
$279,704
Name
Lsu Pennington Biomedical Research Center
Department
None
Type
Organized Research Units
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808
Rebello, Candida J; Greenway, Frank L (2016) Reward-Induced Eating: Therapeutic Approaches to Addressing Food Cravings. Adv Ther 33:1853-1866
Cefalu, William T; Boulton, Andrew J M; Tamborlane, William V et al. (2016) Building Momentum: Taking on the Real “Issues” of Diabetes Care! Diabetes Care 39:10-12
Johnson, William D; Romer, Jacob E (2016) Hypothesis Testing of Population Percentiles via the Wald Test with Bootstrap Variance Estimates. Open J Stat 6:14-24
Kovatchev, Boris; Tamborlane, William V; Cefalu, William T et al. (2016) The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes. Diabetes Care 39:1123-6
Cefalu, William T (2016) "Prediabetes": Are There Problems With This Label? No, We Need Heightened Awareness of This Condition! Diabetes Care 39:1472-7
Obanda, Diana N; Zhao, Peng; Richard, Allison J et al. (2016) Stinging Nettle (Urtica dioica L.) Attenuates FFA Induced Ceramide Accumulation in 3T3-L1 Adipocytes in an Adiponectin Dependent Manner. PLoS One 11:e0150252
Obanda, Diana N; Ribnicky, David; Yu, Yongmei et al. (2016) An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A). Sci Rep 6:22222
Cefalu, William T; Boulton, Andrew J M; Tamborlane, William V et al. (2016) Diabetes Care: "Lagniappe" and "Seeing Is Believing"! Diabetes Care 39:1069-71
Rebello, Candida J; O'Neil, Patrick M; Horn, Deborah B et al. (2016) Timing the discussion of antiobesity medications during obesity treatment. Obesity (Silver Spring) 24:2027-8
Rebello, Candida J; O'Neil, Carol E; Greenway, Frank L (2016) Dietary fiber and satiety: the effects of oats on satiety. Nutr Rev 74:131-47

Showing the most recent 10 out of 151 publications