The Botanical Core of the BRC on Botanicals and Metabolic Syndrome will facilitate the work of all Research Projects, the Integrative Biology Core (IBC) and the Pilot Research and Training Programs. The Botanical Core uses state-of-the-art phytochemical discovery, characterization, standardization and production approaches and modem equipment and greenhouse facilities to perform its mission which include the following specific aims:
Aim 1. The Botanical Core supports the activities of each research project, the IBC and the pilot studies by providing specific services, biochemical tools and methods including: greenhouse-based cultivation of source plants and optimized production of bioactives, production of botanicals for the Center's research, pre-clinical, clinical and pilot studies, activity-guided isolation of bioactives and characterization of their interactions, analytical and structural chemistry support for the research activities, quality control and botanical authentication when necessary and determination of the bioaccessibility and bioavailability of identified active compounds using a gastrointestinal model and plasma analysis.
Aim 2. The Botanical Core collaborates with PIs and with intemal committees to design and perform the experiments and to interpret the results from projects, coordinate plant cultivation, preparation of extracts, fractions and compounds with the PIs'needs for biological testing, develop methods for expedited testing, relate observed biological response to bioaccessibility and bioavailability data.
Aim 3. The Botanical Core assists in design and conduct of pilot studies and in the education and training of new investigators for biobotanical research, provides specific recommendations and/or evaluations of the quality and sourcing of botanical materials to be used for proposed pilot studies and provides all necessary training to investigators and T32 fellows requiring specific skills for the evaluation and use of botanical preparations for in vitro and in vivo models related to metabolic syndrome.
Aim 4. The Botanical Core conducts original research with the following objectives: improve materials, methods and instruments for ongoing projects, create enabling approaches in the advance of new projects, and to continue to screen and identify new candidates and future projects.

Public Health Relevance

The Botanical Core serves a central function to the BRC by supplying the research materials needed by each of the projects and cores with the assurance that the materials are properly identified and characterized for reproducibility and standardization which are the requisite basis for research conducted with botanicals and metabohc syndrome.

National Institute of Health (NIH)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAT1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Lsu Pennington Biomedical Research Center
Baton Rouge
United States
Zip Code
Malina, Andrew; Bryant, Sherrisse K; Chang, Simon H et al. (2014) Capillary electrophoresis-based assay of phosphofructokinase-1. Anal Biochem 447:1-5
Cheng, Diana M; Pogrebnyak, Natalia; Kuhn, Peter et al. (2014) Development and phytochemical characterization of high polyphenol red lettuce with anti-diabetic properties. PLoS One 9:e91571
Cefalu, William T (2014) Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition. J Clin Invest 124:485-7
Graf, Brittany L; Poulev, Alexander; Kuhn, Peter et al. (2014) Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties. Food Chem 163:178-85
Cheng, Diana M; Pogrebnyak, Natalia; Kuhn, Peter et al. (2014) Polyphenol-rich Rutgers Scarlet Lettuce improves glucose metabolism and liver lipid accumulation in diet-induced obese C57BL/6 mice. Nutrition 30:S52-8
Boudreau, Anik; Cheng, Diana M; Ruiz, Carmen et al. (2014) Screening native botanicals for bioactivity: an interdisciplinary approach. Nutrition 30:S11-6
Ribnicky, David M; Roopchand, Diana E; Poulev, Alexander et al. (2014) Artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability and hypoglycemic activity in C57BL/6 mice. Nutrition 30:S4-10
Vance, Katie M; Ribnicky, David M; Rogers, Richard C et al. (2014) Artemisia santolinifolia enhances glutamatergic neurotransmission in the nucleus of the solitary tract. Neurosci Lett 582:115-9
Waterman, Carrie; Cheng, Diana M; Rojas-Silva, Patricio et al. (2014) Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Phytochemistry 103:114-22
Henagan, Tara M; Lenard, Natalie R; Gettys, Thomas W et al. (2014) Dietary quercetin supplementation in mice increases skeletal muscle PGC1? expression, improves mitochondrial function and attenuates insulin resistance in a time-specific manner. PLoS One 9:e89365

Showing the most recent 10 out of 98 publications