Plan of presentation for the Developmental Fund Section. Since this submission is a competitive renewal, we will first present a brief Background to describe how our Developmental Funds have been (and are currently being) used. We believe the """"""""track record"""""""" is the best indicator of success for Developmental Funds. Consequently, summaries of Developmental Fund awards during the current ICMIC will follow. We support four Developmental Fund Projects annually, at $50,000 per project. Projects are for two years, assuming progress in the first year. We stagger projects; in any year, two projects will be in Year 1, and two will be in Year 2. We recently selected Projects 10 and 11 for their first year of funding during the current (05) year. They are presented, in an abbreviated RO-1 application format in this section. They will receive their second year of funding in the next ICMIC funding cycle. Because we have a mechanism in place for selecting Developmental Projects each May, we include two """"""""to be named"""""""" projects to be selected next year for initial funding. In the 2002 competition we had three projects we felt were extraordinary. As a result, we funded three Developmental Projects that year, using Institutional funds. The UCLA Jonsson Comprehensive Cancer Center and the School of Medicine have each agreed to put up a portion of an annual $50,000 commitment to an additional Molecular Imaging Developmental Fund project. While the project will be subject to internal review by the Cancer Center Seed Grant committee (JCCC) and the Stein-Oppenheimer review committee (SOM), Drs. Gasson and Rome have agreed to """"""""earmark"""""""" funds for this purpose - subject to internal peer review.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA086306-08
Application #
7416820
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
8
Fiscal Year
2007
Total Cost
$316,683
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Waldmann, Christopher M; Gomez, Adrian; Marchis, Phillip et al. (2018) An Automated Multidose Synthesis of the Potentiometric PET Probe 4-[18F]Fluorobenzyl-Triphenylphosphonium ([18F]FBnTP). Mol Imaging Biol 20:205-212
Graham, Nicholas A; Minasyan, Aspram; Lomova, Anastasia et al. (2017) Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol 13:914
Balandeh, Mehrdad; Waldmann, Christopher; Shirazi, Daniela et al. (2017) Electrochemical Fluorination and Radiofluorination of Methyl(phenylthio)acetate Using Tetrabutylammonium Fluoride (TBAF). J Electrochem Soc 164:G99-G103
Waldmann, Christopher M; Lebedev, Artem; Allison, Nathaniel et al. (2017) An automated synthesizer for electrochemical 18F-fluorination of organic compounds. Appl Radiat Isot 127:245-252
Lee, Jason T; Zhang, Hanwen; Moroz, Maxim A et al. (2017) Comparative Analysis of Human Nucleoside Kinase-Based Reporter Systems for PET Imaging. Mol Imaging Biol 19:100-108
Barrio, Martin; Czernin, Johannes; Yeh, Michael W et al. (2016) The incidence of thyroid cancer in focal hypermetabolic thyroid lesions: an 18F-FDG PET/CT study in more than 6000 patients. Nucl Med Commun 37:1290-1296
Tavaré, Richard; Escuin-Ordinas, Helena; Mok, Stephen et al. (2016) An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy. Cancer Res 76:73-82
Kirkby, Nicholas S; Chan, Melissa V; Zaiss, Anne K et al. (2016) Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-?B and NFAT transcriptional pathways. Proc Natl Acad Sci U S A 113:434-9
Kim, Woosuk; Le, Thuc M; Wei, Liu et al. (2016) [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proc Natl Acad Sci U S A 113:4027-32
Clark, Peter M; Mai, Wilson X; Cloughesy, Timothy F et al. (2016) Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma. Curr Neurol Neurosci Rep 16:17

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