Quantitative Imaging: Biostatistics and Medical Physics (SR-C). This Specialized Resource provides support for a wide range of imaging (MRI, nuclear and optical imaging) procedures and statistical functions for the clinical trials in ICMIC-3 as well as all the pre-clinical animal research for all Research Projects and Developmental Projects. The tasks and services to be performed by SR-C fall into six broad categories;1) to make additional computational and centralized Image storage facilities available to lCMIC-3 investigators thereby facilitating data sharing between projects;2) to make specialized image processing and display software available, allowing the sharing of the software licenses and centralizing support;3) to provide software development capabilities for the performance of specialized processing and analyses including the automation of bulk processing tasks, format conversions and the development of new algorithms;4) to consult on issues regarding imaging protocols, optimal acquisition settings, quantitation and on the modeling of tracer kinetics;5) to provide biostatistical expertise in the design and analysis of research studies and to conduct statistical analyses and modeling of data generated by those studies;and 6) to conduct research leading to the development of new capabilities of common benefit to the iCMlC-3 projects.

Public Health Relevance

This resource provides essential support for all 4 of the research projects and in addition the developmental projects. It provides the expertise necessary for consolidating the multi-modality pre-clinical small animal imaging studies proposed as well as quantitative imaging requirements of the clinical imaging studies projected in RP1 and RP4 with novel radiopharmaceuticals.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA086438-13
Application #
8567124
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
13
Fiscal Year
2013
Total Cost
$111,654
Indirect Cost
$50,532
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Cheal, Sarah M; Xu, Hong; Guo, Hong-fen et al. (2014) Preclinical evaluation of multistep targeting of diasialoganglioside GD2 using an IgG-scFv bispecific antibody with high affinity for GD2 and DOTA metal complex. Mol Cancer Ther 13:1803-12
de Biasi, Andreas R; Villena-Vargas, Jonathan; Adusumilli, Prasad S (2014) Cisplatin-induced antitumor immunomodulation: a review of preclinical and clinical evidence. Clin Cancer Res 20:5384-91
Vargas, Hebert Alberto; Wassberg, Cecilia; Fox, Josef J et al. (2014) Bone metastases in castration-resistant prostate cancer: associations between morphologic CT patterns, glycolytic activity, and androgen receptor expression on PET and overall survival. Radiology 271:220-9
Adusumilli, Prasad S (2014) Translational immunotherapeutics: chemoimmunotherapy for malignant pleural mesothelioma. Cancer 120:3268-71
Eguchi, Takashi; Kadota, Kyuichi; Park, Bernard J et al. (2014) The new IASLC-ATS-ERS lung adenocarcinoma classification: what the surgeon should know. Semin Thorac Cardiovasc Surg 26:210-22
Zhang, Hanwen; Huang, Ruimin; Pillarsetty, NagaVaraKishore et al. (2014) Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter. Eur J Nucl Med Mol Imaging 41:322-32
Cheal, Sarah M; Punzalan, Blesida; Doran, Michael G et al. (2014) Pairwise comparison of 89Zr- and 124I-labeled cG250 based on positron emission tomography imaging and nonlinear immunokinetic modeling: in vivo carbonic anhydrase IX receptor binding and internalization in mouse xenografts of clear-cell renal cell carcino Eur J Nucl Med Mol Imaging 41:985-94
Zhang, Hanwen; Huang, Ruimin; Cheung, Nai-Kong V et al. (2014) Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clin Cancer Res 20:2182-91
Beattie, Bradley J; Pentlow, Keith S; O'Donoghue, Joseph et al. (2014) A recommendation for revised dose calibrator measurement procedures for 89Zr and 124I. PLoS One 9:e106868
Lee, Ming-Ching; Buitrago, Daniel H; Kadota, Kyuichi et al. (2014) Recent advances and clinical implications of the micropapillary histological subtype in lung adenocarcinomas. Lung Cancer Manag 3:245-253

Showing the most recent 10 out of 119 publications