Abstract

The NCI SPORE guidelines mandate successful efforts to identify and fund developmental research projects, which explore innovative ideas with significant potential to reduce the incidence, morbidity, and mortality of breast cancer or for increasing survival. Both the UAB Breast SPORE and the DAB Comprehensive Cancer Center (UABCCC) have successful track records for obtaining and administering developmental research funds. They have found the SPORE Developmental Research Program to be a most valuable and productive component of the UAB Breast SPORE program. The development of innovative research ideas in breast cancer is critically dependent on the availability of flexible funding. A proportion of the UAB SPORE budget ($100,000 in direct costs) was allocated annually to support developmental research at UAB, the UABCCC, and at affiliated institutions. This is combined with $225,000 committed annually by UAB and the UABCCC, which are flexible funds to be used for both the Developmental and Career Development Programs. Such funding is limited to a maximum of $50,000 per project per year. Funding is for one year and is renewable for one additional year.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA089019-09
Application #
8182313
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
9
Fiscal Year
2010
Total Cost
$115,122
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Wielgos, Monica E; Zhang, Zhuo; Rajbhandari, Rajani et al. (2018) Trastuzumab-Resistant HER2+ Breast Cancer Cells Retain Sensitivity to Poly (ADP-Ribose) Polymerase (PARP) Inhibition. Mol Cancer Ther 17:921-930
Wielgos, Monica E; Rajbhandari, Rajani; Cooper, Tiffiny S et al. (2017) Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors. Mol Cancer Res 15:340-347
Forero, Andres; Li, Yufeng; Chen, Dongquan et al. (2016) Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes. Cancer Immunol Res 4:390-9
McNally, Lacey R; Mezera, Megan; Morgan, Desiree E et al. (2016) Current and Emerging Clinical Applications of Multispectral Optoacoustic Tomography (MSOT) in Oncology. Clin Cancer Res 22:3432-9
Atherton, Daniel S; Sexton, Katherine C; Otali, Dennis et al. (2016) Factors Affecting the Use of Human Tissues in Biomedical Research: Implications in the Design and Operation of a Biorepository. Methods Mol Biol 1381:1-38
Li, Rong; Zhang, Kui; Penedo, Thuy Linh et al. (2016) The RANK Pathway in Advanced Breast Cancer: Does Src Play a Role? Appl Immunohistochem Mol Morphol 24:42-50
Walters, Beth; Thompson, Sunnie R (2016) Cap-Independent Translational Control of Carcinogenesis. Front Oncol 6:128
Wu, Lizhi; Chaudhary, Sandeep C; Atigadda, Venkatram R et al. (2016) Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One 11:e0153556
Otali, D; Fredenburgh, J; Oelschlager, D K et al. (2016) A standard tissue as a control for histochemical and immunohistochemical staining. Biotech Histochem 91:309-26
Hoyt, Kenneth; Umphrey, Heidi; Lockhart, Mark et al. (2015) Ultrasound imaging of breast tumor perfusion and neovascular morphology. Ultrasound Med Biol 41:2292-302

Showing the most recent 10 out of 211 publications