The Administrative Core maintains a central role in guiding SPORE investigators through strong leadership and effective program management. Drs. Lee, Catalona and Stadler have significant expertise in this regard. In response to reviewers'comments in the last submission, we have described in detail the criteria for evaluation of all projects. The Administrative Core is an active command structure that makes the necessary decisions to focus and optimize SPORE research activities in order that they align with high priority areas/goals identified independently, as well as in cooperation with the NCI leadership, the Internal, and the External Advisory Committees. The Core facilitates interactions among the different projects and cores, provides appropriate administrative assistance to investigators in the SPORE and manages all SPORE finances. The Core is responsible for the administration of the Developmental Research and the Career Development Programs. The Core's leadership emphasizes the highest quality in scientific productivity in translational/interventional prostate cancer research and keeps abreast of progress of SPORE projects through coordinating SPORE monthly meetings and meetings of the Internal Advisory Committee and the External Advisory Committee.
The specific aims are: ? To integrate SPORE investigators and encourage intra-SPORE and inter-SPORE interactions ? To provide direction and guidance to the SPORE program to promote scientific progress ? To provide outreach opportunities to engage outside prostate cancer researchers ? To direct the Developmental Research and Career Development Programs such that both new and established investigators are attracted to translational prostate cancer research ? To provide financial and administrative oversight for all SPORE projects and Cores ? To lead monthly SPORE meetings to exchange scientific information ? To lead the meetings of the Internal and External Advisory Committees ? To submit necessary progress reports and other documents to the NCI ? To institute changes necessary to maintain a high level of quality research and ensure that the translational goals of the SPORE are being met, including allocation of discretionary funds. ? To arrange collaborations with other major institutional programs, such as the SPECS program at UC Irvine, the NU Center of Cancer Nanotechnology Excellence {CCNE}, and deCODE Genetics in Iceland.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA090386-10
Application #
8444298
Study Section
Special Emphasis Panel (ZCA1-RPRB-M)
Project Start
Project End
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
10
Fiscal Year
2013
Total Cost
$216,137
Indirect Cost
$47,877
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Hung, Michelle E; Leonard, Joshua N (2016) A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery. J Extracell Vesicles 5:31027
Ye, Cong; Geng, Zhe; Dominguez, Donye et al. (2016) Targeting Ornithine Decarboxylase by α-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells. J Immunol 196:915-23
Kregel, Steven; Chen, James L; Tom, Westin et al. (2016) Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer. Oncotarget 7:26259-74
Nyame, Yaw A; Murphy, Adam B; Bowen, Diana K et al. (2016) Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy. J Clin Oncol 34:1345-9
Pascal, Laura E; Masoodi, Khalid Z; O'Malley, Katherine J et al. (2015) 5α-Reductase inhibition coupled with short off cycles increases survival in the LNCaP xenograft prostate tumor model on intermittent androgen deprivation therapy. J Urol 193:1388-93
Lindholm, Paul F; Sivapurapu, Neela; Jovanovic, Borko et al. (2015) Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-κB Activity. J Clin Cell Immunol 6:
Zhang, Ali; Zhao, Jonathan C; Kim, Jung et al. (2015) LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer. Cell Rep 13:209-21
Hung, Michelle E; Leonard, Joshua N (2015) Stabilization of exosome-targeting peptides via engineered glycosylation. J Biol Chem 290:8166-72
Loeb, Stacy; Sanda, Martin G; Broyles, Dennis L et al. (2015) The prostate health index selectively identifies clinically significant prostate cancer. J Urol 193:1163-9
Jovanovic, Borko D; Subramanian, Hariharan; Helenowski, Irene B et al. (2015) Clinical Trial Laboratory Data Nested With in Subject: Components of Variance, Sample Size and Cost. Biom Biostat Int J 2:

Showing the most recent 10 out of 193 publications