The Biostatistics Core facility will provide statistical support, including related data and computing aspects, for lung cancer research proposed by the SPORE investigators at Dana-Farber/Harvard Cancer Center (DF/HCC). The Core activities will involve collaboration and consultation in genetic epidemiology studies, cell line experiments, animal models, clinical trials and translational analyses with molecular and cellular correlates. In particular, the specific aims are to provide ready and dedicated access to the following: 1. Statistical expertise for design, planning and conduct of research studies. 2. Statistical expertise for data analysis and interpretation, including interim monitoring and scientific reporting. 3. Consultation on developing and implementing plans for data collection and database specifications, including forms design and data entry. 4. Consultation on developing and implementing plans for data management, quality control and administrative reporting. 5. Computing facilities and resources for statistical and related requirements, including data transfer, merging, sharing and security.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA090578-10
Application #
8377869
Study Section
Special Emphasis Panel (ZCA1-GRB-I)
Project Start
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$377,063
Indirect Cost
$70,274
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
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Sofer, Tamar; Schifano, Elizabeth D; Christiani, David C et al. (2017) Weighted pseudolikelihood for SNP set analysis with multiple secondary outcomes in case-control genetic association studies. Biometrics 73:1210-1220
Yin, Jieyun; Liu, Hongliang; Liu, Zhensheng et al. (2017) Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus. Mol Carcinog 56:1663-1672
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Rangachari, Deepa; Le, Xiuning; Shea, Meghan et al. (2017) Cases of ALK-Rearranged Lung Cancer with 5-Year Progression-Free Survival with Crizotinib as Initial Precision Therapy. J Thorac Oncol 12:e175-e177
Ben Khedher, Soumaya; Neri, Monica; Papadopoulos, Alexandra et al. (2017) Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium. Int J Cancer 141:309-323
Feng, Yun; Wang, Yanru; Liu, Hongliang et al. (2017) Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium. Sci Rep 7:825

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