The Biostatistics Core facility will provide statistical support, including related data and computing aspects, for lung cancer research proposed by the SPORE investigators at Dana-Farber/Harvard Cancer Center (DF/HCC). The Core activities will involve collaboration and consultation in genetic epidemiology studies, cell line experiments, animal models, clinical trials and translational analyses with molecular and cellular correlates. In particular, the specific aims are to provide ready and dedicated access to the following: 1. Statistical expertise for design, planning and conduct of research studies. 2. Statistical expertise for data analysis and interpretation, including interim monitoring and scientific reporting. 3. Consultation on developing and implementing plans for data collection and database specifications, including forms design and data entry. 4. Consultation on developing and implementing plans for data management, quality control and administrative reporting. 5. Computing facilities and resources for statistical and related requirements, including data transfer, merging, sharing and security.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA090578-10
Application #
8377869
Study Section
Special Emphasis Panel (ZCA1-GRB-I)
Project Start
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$377,063
Indirect Cost
$70,274
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Shea, Meghan; Costa, Daniel B; Rangachari, Deepa (2016) Management of advanced non-small cell lung cancers with known mutations or rearrangements: latest evidence and treatment approaches. Ther Adv Respir Dis 10:113-29
Kang, Xiaozheng; Liu, Hongliang; Onaitis, Mark W et al. (2016) Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls. Carcinogenesis 37:280-9
Kachuri, Linda; Amos, Christopher I; McKay, James D et al. (2016) Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci. Carcinogenesis 37:96-105
Kinsey, C Matthew; San Jose Estepar, Raul; Van der Velden, Jos et al. (2016) Lower Pectoralis Muscle Area is Associated with a Worse Overall Survival in Non- Small Cell Lung Cancer. Cancer Epidemiol Biomarkers Prev :
Koyama, Shohei; Akbay, Esra A; Li, Yvonne Y et al. (2016) STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment. Cancer Res 76:999-1008
Planchard, David; Besse, Benjamin; Groen, Harry J M et al. (2016) Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial. Lancet Oncol 17:984-93
Patel, Yesha M; Park, Sunghim L; Han, Younghun et al. (2016) Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. Cancer Res 76:5768-5776
Nishino, Mizuki; Dahlberg, Suzanne E; Fulton, Linnea E et al. (2016) Volumetric Tumor Response and Progression in EGFR-mutant NSCLC Patients Treated with Erlotinib or Gefitinib. Acad Radiol 23:329-36
Shea, Meghan; Huberman, Mark S; Costa, Daniel B (2016) Lazarus-Type Response to Crizotinib in a Patient with Poor Performance Status and Advanced MET Exon 14 Skipping Mutation-Positive Lung Adenocarcinoma. J Thorac Oncol 11:e81-2
Sacher, Adrian G; Dahlberg, Suzanne E; Heng, Jennifer et al. (2016) Association Between Younger Age and Targetable Genomic Alterations and Prognosis in Non-Small-Cell Lung Cancer. JAMA Oncol 2:313-20

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