The GI SPORE Administrative Core supports projects and investigators by managing SPORE resources, communication and outreach, and by fostering the interaction among investigators, collaborators, other VICC SPOREs, other GI SPOREs, the patient and advocate community and the NCI. This management and support is accomplished by administrative and scientific meetings of SPORE investigators with oversight provided by the Internal and External Advisory Boards. Specific functions of the Core include: 1. To coordinate all GI SPORE cancer-related research 2. To administer the Developmental Research Program (DRP) 3. To administer the Career Development Program (CDP) 4. To create and prepare documents and reports to ensure compliance with federal regulations and reporting requirements 5. To monitor and manage financial resources 6. To serve as the point of contact for GI SPORE investigators and patient advocates 7. To organize and schedule GI SPORE project meetings for oversight, communication, administration, evaluation, collaboration, outreach and education 8. To coordinate communications with other GI SPOREs, VU SPOREs, VICC, VUMC, Epithelial Biology Center (EBC), Ayers Institute, Digestive Diseases Research Center (DDRDC) and collaborators 9. To organize annual External and Internal Advisory Board (EAB &IAB) meetings 10. To organize, along with the other Vanderbilt Lung and Breast SPORE administrative cores, the quarterly VICC SPORE PI meetings 11. To proactively identify academic (Meharry Medical College, Melbourne University) and pharmaceutical (GE Healthcare, Novartis) interactions that will enhance the conduct of the GI SPORE program, taking special advantage of opportunities provided through Vanderbilt's Clinical &Translational &Science Award (CTSA)

Public Health Relevance

The Administrative Core supports SPORE projects and investigators by managing SPORE resources, communication and outreach, including fostering Interaction among SPORE components and collaborators, other SPORES, the community and the NCI.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-RPRB-M)
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Vanderbilt University Medical Center
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Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315
Idrees, Kamran; Padmanabhan, Chandrasekhar; Liu, Eric et al. (2018) Frequent BRAF mutations suggest a novel oncogenic driver in colonic neuroendocrine carcinoma. J Surg Oncol 117:284-289
Zhang, Qin; Jeppesen, Dennis K; Higginbotham, James N et al. (2018) Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Cell Mol Gastroenterol Hepatol 5:627-629.e6
Choksi, Yash A; Reddy, Vishruth K; Singh, Kshipra et al. (2018) BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol 11:1363-1374
Saito-Diaz, Kenyi; Benchabane, Hassina; Tiwari, Ajit et al. (2018) APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Dev Cell 44:566-581.e8
Davenport, James R; Su, Timothy; Zhao, Zhiguo et al. (2018) Modifiable lifestyle factors associated with risk of sessile serrated polyps, conventional adenomas and hyperplastic polyps. Gut 67:456-465
Liu, Qi; Herring, Charles A; Sheng, Quanhu et al. (2018) Quantitative assessment of cell population diversity in single-cell landscapes. PLoS Biol 16:e2006687
Means, Anna L; Freeman, Tanner J; Zhu, Jing et al. (2018) Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. Cell Mol Gastroenterol Hepatol 6:257-276
Weiss, Vivian L; Kiernan, Colleen; Wright, Jesse et al. (2018) Fine-Needle Aspiration-Based Grading of Pancreatic Neuroendocrine Neoplasms Using Ki-67: Is Accurate WHO Grading Possible on Cytologic Material? J Am Soc Cytopathol 7:154-459
Roberts, Jordan; Gonzalez, Raul S; Revetta, Frank et al. (2018) Mesenteric tumour deposits arising from small-intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4-expressing plasma cells. Histopathology 73:795-800

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