The Leadership and Administrative Core (LAC) will serve to integrate and enhance the research conducted by the SPORE projects and cores, as well as the Career Development faculty and investigators supported through the Developmental Research Program, through the application of general administrative support and the facilitation of communication and data dissemination. The Core will also provide the formal links between the following entities: (1) All investigators comprising the Pacific Northwest (PNW) SPORE in prostate cancer;(2) Advisory Panels (e.g., External Advisory Board [EAB], Internal Advisory Board [lAB], etc.);(3) Review Panels evaluating Career Development and Developmental Research proposals;(4) Those institutional structures (e.g. FHCRC and other SPORE participatory sites) with laboratories and clinical facilities wherein occur the research and education components of the SPORE;and (5) Representatives of the National Cancer Institute (NCI). This Leadership and Administrative Core has the following Specific Aims:
Specific Aim 1. To provide oversight of all SPORE activities involving the independent research projects, the Career Development Program (CDP), the Developmental Research Program (DRP), the shared resource cores, and the parent institutions.
Specific Aim 2. To provide the organizational structure, based on a group of interacting committees, for supporting and evaluating the key objectives of the PNW SPORE.
Specific Aim 3. To organize and coordinate forums for interactions of the Executive Committee, Internal Advisory Board, and External Advisory Board.
Specific Aim 4. To provide efficient and effective fiscal management of grant funds.
Specific Aim 5. To communicate and consult with the NCI Project Officer(s) and staff in the preparation of required progress reports, publications lists, and regulatory documents.
Specific Aim 6. To develop and maintain virtual mechanisms that efficiently facilitates multi-institutional intra- and inter-SPORE interactions.

Public Health Relevance

The ongoing successful functioning of the PNW prostate cancer SPORE is highly dependent upon the effective and efficient operations provided by the Administrative Core. The Core will continue to be the hub for SPORE-related management, education, and communication within and across the four SPORE institutions, and it is vital for carrying out the overall scientific and translational mission of the SPORE.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-RPRB-M (M1))
Program Officer
Hruszkewycz, Andrew M
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Fred Hutchinson Cancer Research Center
United States
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Viswanathan, Srinivas R; Ha, Gavin; Hoff, Andreas M et al. (2018) Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing. Cell 174:433-447.e19
Armenia, Joshua; Wankowicz, Stephanie A M; Liu, David et al. (2018) The long tail of oncogenic drivers in prostate cancer. Nat Genet 50:645-651
Plymate, Stephen R; Sharp, Adam; de Bono, Johann S (2018) Nuclear Circulating Tumor Cell Androgen Receptor Variant 7 in Castration-Resistant Prostate Cancer: The Devil Is in the Detail. JAMA Oncol 4:1187-1188
Russo, Joshua W; Gao, Ce; Bhasin, Swati S et al. (2018) Downregulation of Dipeptidyl Peptidase 4 Accelerates Progression to Castration-Resistant Prostate Cancer. Cancer Res 78:6354-6362
Sowalsky, Adam G; Ye, Huihui; Bhasin, Manoj et al. (2018) Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations. Cancer Res 78:4716-4730
Zhu, Yezi; Sharp, Adam; Anderson, Courtney M et al. (2018) Novel Junction-specific and Quantifiable In Situ Detection of AR-V7 and its Clinical Correlates in Metastatic Castration-resistant Prostate Cancer. Eur Urol 73:727-735
Chalfin, Heather J; Glavaris, Stephanie A; Malihi, Paymaneh D et al. (2018) Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms. J Urol 199:1494-1501
Inoue, Lurdes Y T; Lin, Daniel W; Newcomb, Lisa F et al. (2018) Comparative Analysis of Biopsy Upgrading in Four Prostate Cancer Active Surveillance Cohorts. Ann Intern Med 168:1-9
Cheng, Heather H; Plets, Melissa; Li, Hongli et al. (2018) Circulating microRNAs and treatment response in the Phase II SWOG S0925 study for patients with new metastatic hormone-sensitive prostate cancer. Prostate 78:121-127
Levesque, Christine; Nelson, Peter S (2018) Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance. Cold Spring Harb Perspect Med 8:

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