This competitive renewal application for a Specialized Program of Research Excellence (SPORE) in Cervical Cancer at Johns Hopkins University School of Medicine, University of Alabama at Birmingham, University of Colorado and our new collaborator Mount Sinai Icahn School of Medicine brings together a highly interactive, multidisciplinary, and inter-institutional program of translational research in cervical cancer. Th SPORE includes five integrated projects spanning the fields of prevention and treatment cervical cancer and its precursor lesions. Project 1: L1 capsomeres as a next generation preventive HPV vaccine, led by Robert Garcea, M.D. and Warner Huh, M.D. Project 2: Local vaccination and imiquimod for persistent HPV16+ patients with normal cytology, led by Richard Roden, Ph.D., Warner Huh, M.D. and T.-C. Wu, M.D., Ph.D. Project 3: Treatment of HIV- and HIV+ patients with CIN2/3 using an HPV DNA vaccine administered intramuscularly via electroporation, led by Ronald Alvarez, M.D., Chien-Fu Hung, Ph.D. and Richard Roden, Ph.D. Project 4: Molecular attributes of tissue immune response in HPV disease, led by Cornelia Trimble, M.D. and Michael Donovan, M.D., Ph.D. Project 5: Safety and immunogenicity study of a HPV16-specific therapeutic protein administered intratumorally during chemoradiation, led by Ronald Alvarez, M.D., Richard Roden, Ph.D. and T.-C. Wu, M.D., Ph.D. The five integrated projects are supported by three cores that provide critical supportive infrastructure essential to efficient and effective translational research: the Administrative/Communication Core (Core A), led by T.-C. Wu, M.D., Ph.D. and Edward Partridge, M.D., the Biostatistics/Data Management Core (Core B), led by Sejong Bae Ph.D., Karan Singh, Ph.D., and Chenguang Wang, Ph.D. and the Tissue/Pathology and Immunology Core (Core C), led by Cornelia Trimble, M.D. and Lawrence Lamb, Ph.D. The SPORE also includes a Developmental Research Program (led by T.- C. Wu, M.D., Ph.D. and Drew Pardoll M.D., Ph.D.) to nurture novel research ideas and technologies and a Career Development Program (led by T.-C. Wu, M.D., Ph.D. and Edward Partridge, M.D.) to recruit and facilitate career development of individuals with interest in translational cervical cancer research.

Public Health Relevance

This research program provides a spectrum of capabilities, driving innovative translational research for improved prevention and treatment of cervical cancer to better patient outcomes and our understanding of cancer biology and immunology

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
2P50CA098252-11
Application #
8740662
Study Section
Special Emphasis Panel (ZCA1-RPRB-C (M1))
Program Officer
Kuzmin, Igor A
Project Start
2003-09-30
Project End
2019-08-31
Budget Start
2014-09-24
Budget End
2015-08-31
Support Year
11
Fiscal Year
2014
Total Cost
$2,162,000
Indirect Cost
$493,605
Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Banet, Natalie; Gown, Allen M; Shih, Ie-Ming et al. (2015) GATA-3 expression in trophoblastic tissues: an immunohistochemical study of 445 cases, including diagnostic utility. Am J Surg Pathol 39:101-8
Wu, Chao-Yi; Yang, Li-Hua; Yang, Huang-Yu et al. (2014) Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors. Clin Cancer Res 20:644-57
Zhao, Rui-Xun; Xu, Zhi-Xiang (2014) Targeting the LKB1 tumor suppressor. Curr Drug Targets 15:32-52
Kwak, Kihyuck; Jiang, Rosie; Wang, Joshua W et al. (2014) Impact of inhibitors and L2 antibodies upon the infectivity of diverse alpha and beta human papillomavirus types. PLoS One 9:e97232
Coughlin, Kathleen; Anchoori, Ravi; Iizuka, Yoshie et al. (2014) Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses. Clin Cancer Res 20:3174-86
Wang, Joshua W; Jagu, Subhashini; Wang, Chenguang et al. (2014) Measurement of neutralizing serum antibodies of patients vaccinated with human papillomavirus L1 or L2-based immunogens using furin-cleaved HPV Pseudovirions. PLoS One 9:e101576
Paul, Proma; Tanner, Amanda E; Gravitt, Patti E et al. (2014) Acceptability of HPV vaccine implementation among parents in India. Health Care Women Int 35:1148-61
Soong, Ruey-Shyang; Song, Liwen; Trieu, Janson et al. (2014) Direct T cell activation via CD40 ligand generates high avidity CD8+ T cells capable of breaking immunological tolerance for the control of tumors. PLoS One 9:e93162
Zhang, Huang-Ge; Grizzle, William E (2014) Exosomes: a novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions. Am J Pathol 184:28-41

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