This SPORE recognizes that a sustained, dynamic and cutting-edge program to improve patient outcomes is dependent upon attracting the most promising young scientists to study cervical cancer and nurturing their careers. We further recognize the importance of seeking out such talent among minorities and women, and helping these faculty members overcome barriers to flourish as independent scientists with thoughtful mentorship and practical help. The Career Development Program of the Cervical Cancer SPORE continues to attract and stimulate young investigators to carry out translational research related to cervical cancer and provide mentorship. Candidates submit an application and are evaluated through a careful selection process involving a career development committee headed by Dr. T.-C. Wu, the SPORE PI as well as the SPORE steering committee. Dr. Partridge, the Clinical Research Director for SPORE from University of Alabama at Birmingham (UAB) assists in the translational and clinical efforts of awarded investigators. Recipients of the award are reviewed annually and investigators are required to submit an annual progress report subject to the aforementioned review process. In addition, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (JHU) also provides $75,000 annually as match funds for the Career Development Program. UAB will also contribute $40,000 annually to be used in the Career Development or Developmental Research Programs. This continues to be an impactful program that has recruited and developed a cadre of outstanding translational scientists, including several new leaders in this Cervical Cancer SPORE, and incorporated their innovations and expertise into this program. We are excited about our new collaboration with Mount Sinai School of Medicine, and reaching out to their young faculty. Specific Goals To attract, select and mentor promising young scientists with a special emphasis on recruiting qualified women and minorities. To develop and support the awardee?s rigorous and innovative translational research program addressing cervical cancer

National Institute of Health (NIH)
National Cancer Institute (NCI)
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Special Emphasis Panel (ZCA1-RPRB-C (M1))
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Johns Hopkins University
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Wang, Joshua W; Hung, Chein-Fu; Huh, Warner K et al. (2015) Immunoprevention of human papillomavirus-associated malignancies. Cancer Prev Res (Phila) 8:95-104
Banet, Natalie; Gown, Allen M; Shih, Ie-Ming et al. (2015) GATA-3 expression in trophoblastic tissues: an immunohistochemical study of 445 cases, including diagnostic utility. Am J Surg Pathol 39:101-8
Wu, Chao-Yi; Yang, Li-Hua; Yang, Huang-Yu et al. (2014) Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors. Clin Cancer Res 20:644-57
Zhao, Rui-Xun; Xu, Zhi-Xiang (2014) Targeting the LKB1 tumor suppressor. Curr Drug Targets 15:32-52
Kwak, Kihyuck; Jiang, Rosie; Wang, Joshua W et al. (2014) Impact of inhibitors and L2 antibodies upon the infectivity of diverse alpha and beta human papillomavirus types. PLoS One 9:e97232
Coughlin, Kathleen; Anchoori, Ravi; Iizuka, Yoshie et al. (2014) Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses. Clin Cancer Res 20:3174-86
Wang, Joshua W; Jagu, Subhashini; Wang, Chenguang et al. (2014) Measurement of neutralizing serum antibodies of patients vaccinated with human papillomavirus L1 or L2-based immunogens using furin-cleaved HPV Pseudovirions. PLoS One 9:e101576
Paul, Proma; Tanner, Amanda E; Gravitt, Patti E et al. (2014) Acceptability of HPV vaccine implementation among parents in India. Health Care Women Int 35:1148-61
Soong, Ruey-Shyang; Song, Liwen; Trieu, Janson et al. (2014) Direct T cell activation via CD40 ligand generates high avidity CD8+ T cells capable of breaking immunological tolerance for the control of tumors. PLoS One 9:e93162
Zhang, Huang-Ge; Grizzle, William E (2014) Exosomes: a novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions. Am J Pathol 184:28-41

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