The goal of the Career Development Program of this uterine SPORE is to develop highly trained investigators dedicated to translational studies in human uterine cancer. The program will 1) recruit and train physician and basic science postdoctoral fellows to enable them to become highly skilled translational investigators in the field of uterine cancer, 2) provide specific knowledge of research in uterine cancer that will enhance the ability of awardees to conduct innovative translational science that will direcfiy impact on the understanding and treatment of this disease, and 3) redirect individuals who already have shown considerable scientific promise into uterine cancer research. The unique educational environment that exists at UT M.D. Anderson Gancer Center, the University of Texas Health Science Center, and the other institutions of the Texas Medical Center will add much to achieving these goals. Solicitations will be made for qualified candidates from UT M.D. Anderson Gancer Center, including physicians in our Gynecological Oncology and Pathology fellowship programs, basic science graduates of our Graduate School of Biomedical Sciences, and residents/fellows in the Department of Obstetrics, Gynecology, and Reproductive Sciences at the UT Houston Medical School, as well M.D. and Ph.D. candidates identified by national advertisements. The Career Development Selecfion Committee will interview the candidates, make the final selection of fellows, and approve the placement of the trainee in a research laboratory making this decision based upon the interests and research experience of the trainee and the availability of suitable resources. Minorities and women will be encouraged to apply. In addifion to research training via their individual projects, fellows will participate in activities designed to provide an overview of current knowledge, problems, and opportunities in uterine cancer research, state-of-the-art techniques and approaches for translafional research, career development activities such as grant preparafion and seminar presentations, and the opportunities to interact with established senior invesfigators in human uterine cancer research. This program will be directed by George M. Stancel, Ph.D.. Dean of the University of Texas Graduate School of Biomedical Sciences. David M. Gershenshon, M.D., Chairman of Gynecological Oncology at M. D Anderson, and Diane C. Bodurka, M.D., Gynecologic Oncologist at M. D. Anderson and Director of the Gynecologic Oncology Fellowship Program at M. D. Anderson Gancer Center. All have extensive mentoring experience.

Public Health Relevance

The purpose of the M. D. Anderson Uterine SPORE Career Development Program is to support the development of young investigators who intend to focus their careers on translational studies of endometrial cancer and who have not yet received peer-reviewed funding but who have potential as leaders in this field.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA098258-10
Application #
8724922
Study Section
Special Emphasis Panel (ZCA1-RPRB-M)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
10
Fiscal Year
2014
Total Cost
$79,126
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Rupaimoole, Rajesha; Calin, George A; Lopez-Berestein, Gabriel et al. (2016) miRNA Deregulation in Cancer Cells and the Tumor Microenvironment. Cancer Discov 6:235-46
Srivastava, Akhil; Babu, Anish; Filant, Justyna et al. (2016) Exploitation of Exosomes as Nanocarriers for Gene-, Chemo-, and Immune-Therapy of Cancer. J Biomed Nanotechnol 12:1159-73
Yuan, Ying; Hess, Kenneth R; Hilsenbeck, Susan G et al. (2016) Bayesian Optimal Interval Design: A Simple and Well-Performing Design for Phase I Oncology Trials. Clin Cancer Res 22:4291-301
Haemmerle, Monika; Bottsford-Miller, Justin; Pradeep, Sunila et al. (2016) FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal. J Clin Invest 126:1885-96
Westin, Shannon N; Sun, Charlotte C; Tung, Celestine S et al. (2016) Survivors of gynecologic malignancies: impact of treatment on health and well-being. J Cancer Surviv 10:261-70
McCampbell, A S; Mittelstadt, M L; Dere, R et al. (2016) Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity. Curr Mol Med 16:252-65
Guo, Beibei; Li, Yisheng; Yuan, Ying (2016) A dose-schedule finding design for phase I-II clinical trials. J R Stat Soc Ser C Appl Stat 65:259-272
Liu, Joyce; Westin, Shannon N (2016) Rational selection of biomarker driven therapies for gynecologic cancers: The more we know, the more we know we don't know. Gynecol Oncol 141:65-71
Wang, Chao; Zhu, Xiaoyong; Feng, Weiwei et al. (2016) Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm. Am J Cancer Res 6:27-37
Chen, Tenghui; Wang, Zixing; Zhou, Wanding et al. (2016) Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types. BMC Genomics 17 Suppl 2:394

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