The overall purpose of the Biostatistics Core ofthe UAB/UMN SPORE in Pancreatic Cancer is to contribute to the science and operation of the SPORE by participating fully in its activities. This includes participation in project development from the outset. The Core, is a joint activity of the Biostatistics and Informatics Core of University of Minnesota Cancer Center and the Biostatistics and Bioinformatics Shared Facility of the Comprehensive Cancer Center of the University of Alabama. Specifically, we will provide biostatistical consultation and support by assisting in experimental design and the collection, visualization, analysis, quantitative modeling, interpretation, and publication for all SPORE projects and cores;develop new or adapt existing biostatistical methods as needed and appropriate, provide assistance with the identification and solution of complex database tasks arising in the course of SPORE activities particularly for the tissue and clinical cores, develop new or adapt existing data management techniques and systems as needed, implement appropriate Quality Assurance (QA) plans for all data collection activities, and work closely with the SPORE leaders to implement the Developmental Research Program and the Career Development Program. The Core includes a team of 8 faculty statisticians from the two institutions who have developed a productive management plan to coordinate activities and to handle SPORE data and analyses with state of the art approaches. Two lead statisticians are designated for each project and a member also will work with the other two Cores and with the projects in the Developmental Research Program and the Career Development Program. One member will serve on the mentorship team proposed for fellows selected for this program. Databases systems will meet the appropriate regulatory requirements and will be based at UAB in the Division of Preventive Medicine In a highly secure system with full redundancy in back ups.

Agency
National Institute of Health (NIH)
Type
Specialized Center (P50)
Project #
5P50CA101955-10
Application #
8707209
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Ramesh, Jayapal; Kim, Hwasoon; Reddy, Kartika et al. (2014) Impact of pancreatic stent caliber on post-endoscopic retrograde cholangiopancreatogram pancreatitis rates in patients with confirmed sphincter of Oddi dysfunction. J Gastroenterol Hepatol 29:1563-7
Kaliberov, S A; Kaliberova, L N; Buchsbaum, D J et al. (2014) Experimental virotherapy of chemoresistant pancreatic carcinoma using infectivity-enhanced fiber-mosaic oncolytic adenovirus. Cancer Gene Ther 21:264-74
Bohrer, Laura R; Chuntova, Pavlina; Bade, Lindsey K et al. (2014) Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation. Cancer Res 74:374-86
Dmitriev, Igor P; Kashentseva, Elena A; Kim, Kenneth H et al. (2014) Monitoring of biodistribution and persistence of conditionally replicative adenovirus in a murine model of ovarian cancer using capsid-incorporated mCherry and expression of human somatostatin receptor subtype 2 gene. Mol Imaging 13:
Chio, Iok In Christine; Yordanov, Georgi; Tuveson, David (2014) MAX-ing out MYC: a novel small molecule inhibitor against MYC-dependent tumors. J Natl Cancer Inst 106:
Auer, H; Mobley, J A; Ayers, L W et al. (2014) The effects of frozen tissue storage conditions on the integrity of RNA and protein. Biotech Histochem 89:518-28
Hébert-Magee, Shantel; Varadarajulu, Shyam; Frost, Andra R et al. (2014) Primary pancreatic leiomyosarcoma: a rare diagnosis obtained by EUS-FNA cytology. Gastrointest Endosc 80:361-2
Kim, Hyunki; Rigell, Christopher J; Zhai, Guihua et al. (2014) Antagonistic effects of anti-EMMPRIN antibody when combined with chemotherapy against hypovascular pancreatic cancers. Mol Imaging Biol 16:85-94
Reddy, Kartika; Hooper, Kari; Frost, Andra et al. (2014) Intraductal papillary carcinoma of common bile duct diagnosed by endoscopic ultrasound-guided fine-needle aspiration. Endoscopy 46 Suppl 1 UCTN:E248-9
Desai, Leena P; Zhou, Yong; Estrada, Aida V et al. (2014) Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein. J Biol Chem 289:18270-8

Showing the most recent 10 out of 53 publications