The Imaging and Probes Resource will provide a seamless translational approach that will integrate multimodality MR, PET, SPECT, and optical imaging and probe development to understand and effectively treat cancer. The research studies in this JHU ICMIC application require a wide range of imaging methods and imaging probe development that span the imaging of microscopic structures such as collagen 1 fibers, to preclinical imaging of human cancer xenografts and transgenic models, to imaging cancer patients. This resource will provide the requisite infrastructure and act as a central resource for JHU ICMIC investigators to obtain expertise and assistance for multi-modality imaging, image visualization and analyses, and imaging probe development. This resource will also perform research and development in imaging and probe development in the JHU ICMIC. The resource will play a valuable role in identifying and developing novel imaging technologies and probes as individual research projects evolve within the program.
The aims of this resource are to: (i) Guide and assist investigators in the use of imaging technologies, and to identify the most appropriate imaging technology for the research studies, (ii) Develop and provide state-of- the-art image analyses and visualization necessary for multi-modality imaging data, (iii) Identify, develop, and provide novel contrast agents for MR, radionuclide, and optical imaging applications, (iv) Develop agents against critical targets identified during the course of the research programs in the center, (v) Identify the most promising preclinical Imaging techniques and agents for future clinical use. Members of this resource are versatile in imaging and probe development and can function interchangeably in this resource resulting in a commonality of effort.
The Imaging and Probes Resource is a cornerstone of our JHU ICMIC as it is the centralized resource that assists investigators in imaging and probe development. It will also lead advances in imaging and probes, and interact with the Molecular Oncology Resource in advancing our purpose of applying molecular imaging to advance cancer discovery and treatment.
|Winnard Jr, Paul T; Bharti, Santosh K; Penet, Marie-France et al. (2016) Detection of Pancreatic Cancer-Induced Cachexia Using a Fluorescent Myoblast Reporter System and Analysis of Metabolite Abundance. Cancer Res 76:1441-50|
|Chan, Kannie W Y; Jiang, Lu; Cheng, Menglin et al. (2016) CEST-MRI detects metabolite levels altered by breast cancer cell aggressiveness and chemotherapy response. NMR Biomed 29:806-16|
|Azad, Babak Behnam; Chatterjee, Samit; Lesniak, Wojciech G et al. (2016) A fully human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts. Oncotarget 7:12344-58|
|Penet, Marie-France; Chen, Zhihang; Mori, Noriko et al. (2016) Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy. Methods Mol Biol 1372:37-47|
|Xu, Xiang; Yadav, Nirbhay N; Zeng, Haifeng et al. (2016) Magnetization transfer contrast-suppressed imaging of amide proton transfer and relayed nuclear overhauser enhancement chemical exchange saturation transfer effects in the human brain at 7T. Magn Reson Med 75:88-96|
|Mascini, Nadine E; Cheng, Menglin; Jiang, Lu et al. (2016) Mass Spectrometry Imaging of the Hypoxia Marker Pimonidazole in a Breast Tumor Model. Anal Chem 88:3107-14|
|Chatterjee, Samit; Lesniak, Wojciech G; Gabrielson, Matthew et al. (2016) A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors. Oncotarget 7:10215-27|
|Penet, Marie-France; Kakkad, Samata; Pathak, Arvind P et al. (2016) Structure and Function of a Prostate Cancer Dissemination Permissive Extracellular Matrix. Clin Cancer Res :|
|Lesniak, Wojciech G; Oskolkov, Nikita; Song, Xiaolei et al. (2016) Salicylic Acid Conjugated Dendrimers Are a Tunable, High Performance CEST MRI NanoPlatform. Nano Lett 16:2248-53|
|Behnam Azad, Babak; Lisok, Ala; Chatterjee, Samit et al. (2016) Targeted Imaging of the Atypical Chemokine Receptor 3 (ACKR3/CXCR7) in Human Cancer Xenografts. J Nucl Med 57:981-8|
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