The use of appropriate biostatistical tools is an essential requirement for comprehensive study planning and correct interpretation of data. This resource will provide statistical expertise, guidance, and analyses to the JHU ICMIC investigators in designing their research studies and interpreting their data.
Our specific aims are: (i) To provide comprehensive biostatistics and bioinformatics consultation to all projects in the JHU ICMIC, assisting in design, collection, visualization, analysis, and interpretation of data arising in the course of research activities, (ii) To provide the infrastructural support for quality assurance, data storage and processing, and all informatics activities necessary to successfully perform Aim 1 successfully, (iii) To provide annual analyses of all compiled data to discover new associations that can stimulate new testable hypothesis. The Biostatistics Resource will be housed in the Division of Oncology Biostatistics at the Sidney Kimmel Comprehensive Cancer Center and the Department of Oncology. The resource members will have an integral role in the scientific development, study design, execution, and analysis of all research data. Resource investigators have extensive and complementary experiences in biostatistics and bioinformatics methodological development and their applications. Members of the Biostatistics Resource are committed to taking a direct interest in the substantive issues being investigated, to participating in regular project and program meetings, and to providing rigorous and innovative input on all quantitative matters arising in the projects. By contributing to multiple projects, this resource will also be in a position to promote interdisciplinary interactions among projects. This resource will provide the requisite infrastructure and act as a central resource for JHU ICMIC investigators to obtain expertise and assistance for biostatistical analyses. The resource director will provide leadership and oversight and will form part of the Oversight Committee that will meet at least on a monthly basis, and more frequently if necessary, with the JHU ICMIC Director to discuss and allocate use of the resource.

Public Health Relevance

The Biostatistics Resource will provide a seamless integration of biostatistical expertise through all components of the JHU ICMIC. It will serve as a centralized resource to all JHU ICMIC investigators and promote synergy across different projects and resources. It will provide comprehensive biostatistics consultation and collaboration for all the research studies undertaken in the JHU ICMIC.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA103175-09
Application #
8728588
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
2014-08-01
Project End
2016-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
9
Fiscal Year
2014
Total Cost
$83,405
Indirect Cost
$30,023
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Chan, Kannie W Y; Jiang, Lu; Cheng, Menglin et al. (2016) CEST-MRI detects metabolite levels altered by breast cancer cell aggressiveness and chemotherapy response. NMR Biomed 29:806-16
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Chatterjee, Samit; Lesniak, Wojciech G; Gabrielson, Matthew et al. (2016) A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors. Oncotarget 7:10215-27
Penet, Marie-France; Kakkad, Samata; Pathak, Arvind P et al. (2016) Structure and Function of a Prostate Cancer Dissemination Permissive Extracellular Matrix. Clin Cancer Res :
Lesniak, Wojciech G; Oskolkov, Nikita; Song, Xiaolei et al. (2016) Salicylic Acid Conjugated Dendrimers Are a Tunable, High Performance CEST MRI NanoPlatform. Nano Lett 16:2248-53
Behnam Azad, Babak; Lisok, Ala; Chatterjee, Samit et al. (2016) Targeted Imaging of the Atypical Chemokine Receptor 3 (ACKR3/CXCR7) in Human Cancer Xenografts. J Nucl Med 57:981-8

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