Core B, the Biostatistics and Research Informatics Core (BRIC) of the City of Hope Lymphoma SPORE, provides statistical expertise across all SPORE research activities, including study design, safety monitoring, data collection, data quality assurance, data analysis, and multi-center study site coordination. BRIC will ensure that the proposed research hypotheses will be addressed with appropriate measures, tests, and interpretation, whether the data come from epidemiological studies, basic science, translational, immunologic studies, imaging, or clinical trials. The centralized, comprehensive framework of BRIC assures each SPORE investigator access to statistical experts who have appropriate experience, interests and time to engage in the collaborative development of study designs, analysis plans, data analysis, interpretation, and abstract /manuscript preparation. The BRIC will also provide infrastructure for the management and integration of both existing and newly collected data through consistent and compatible data handling. The Core plays an integral role in the scientific development, execution, and analysis of ail projects in the SPORE, including the clinical trials Core investigators have extensive experience in quantitative methods for biomedical applications, including clinical, basic, and translational science studies, particularly in hematologic malignancies. BRIC is committed to collaboration, to help ensure the scientific integrity of the SPORE investigations, by participating in regular project and program meetings, and providing rigorous and innovative input on all statistical and information management matters arising within the projects.
The specific aims of BRIC are as follows:
Specific Aim 1. To support high quality data management through state-of-the-art information technologies, ensuring standardization, quality assurance, security, training, monitoring, and data integration, and multicenter coordination when appropriate.
Specific Aim 2. To provide biostatistical support to the Projects, Cores and Programs, by consulting on the design, data monitoring, analysis, statistical modeling, visualization, interpretation and publication of the data generated by SPORE activities.

Public Health Relevance

As a critical shared resource of the Lymphoma SPORE, the purpose of the Biostatistics and Research Informatics Core (BRIC) is to provide the essential information management, quality assurance, experimental design, and biostatistical analysis resources required to conduct the ongoing and planned investigations of lymphoid malignancies.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-GRB-I)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
City of Hope/Beckman Research Institute
United States
Zip Code
Jonnalagadda, Mahesh; Mardiros, Armen; Urak, Ryan et al. (2015) Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy. Mol Ther 23:757-68
Lacoste, Sandrine; Bhatia, Ravi; Bhatia, Smita et al. (2014) Granulocytes affect double-strand break repair assays in primary human lymphocytes. PLoS One 9:e93185
Herrmann, Andreas; Priceman, Saul J; Swiderski, Piotr et al. (2014) CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells. J Clin Invest 124:2977-87
Chadalavada, Deepti; Adamson, Trinka W; Burnett, John C et al. (2014) Irradiated compared with nonirradiated NSG mice for the development of a human B-cell lymphoma model. Comp Med 64:179-85
Yang, Chunmei; Lee, Heehyoung; Pal, Sumanta et al. (2013) B cells promote tumor progression via STAT3 regulated-angiogenesis. PLoS One 8:e64159
Xin, Hong; Lu, Rongze; Lee, Heehyoung et al. (2013) G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells. J Biol Chem 288:13842-9
Zhou, Jiehua; Tiemann, Katrin; Chomchan, Pritsana et al. (2013) Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells. Nucleic Acids Res 41:4266-83
Ng, Thomas S C; Wert, David; Sohi, Hargun et al. (2013) Serial diffusion MRI to monitor and model treatment response of the targeted nanotherapy CRLX101. Clin Cancer Res 19:2518-27
Jonnalagadda, M; Brown, C E; Chang, W C et al. (2013) Efficient selection of genetically modified human T cells using methotrexate-resistant human dihydrofolate reductase. Gene Ther 20:853-60
Yang, Chunmei; Lee, Heehyoung; Jove, Veronica et al. (2013) Prognostic significance of B-cells and pSTAT3 in patients with ovarian cancer. PLoS One 8:e54029

Showing the most recent 10 out of 59 publications