A fundamental component of the translational research of the The University of Texas MD Anderson Cancer Center Brain Cancer SPORE is conduct of focused translational research involving human tissue and blood specimens, allowing investigation of the biology of target and normal tissues, and evaluation of treatment effects on both target and normal tissue and on modulation of specific, relevant biomarkers. The Pathology and Biorepository Core collects, processes and maintains human tissue specimens from patients and will disperse these tissues and tissue-derived primary glioma stem cell (GSC) to SPORE investigators. It has been an effective resource for the existing SPORE projects, which are heavily tissue- dependent and will continue to serve this function in the proposed SPORE Projects going forward. The specific objectives of the Pathology and Biorepository Core are these: Objective 1 Maintain and enhance a repository of tumor tissue and matched blood specimens from patients with central.nervous system (CNS) tumors receiving care at MD Anderson Cancer Center Objective 2 Provide comprehensive histologic characterization of tissue samples used in SPORE projects, including specimens from patients and experimental tumors in animals;expeditiously distribute tissue specimens to SPORE investigators for analysis and provide expertise in the interpretation of studies performed on tissue sections within SPORE projects Objective 3 Offer centralized services, including immunohistochemical characterization of biomarkers, tissue array design and construction and primary GSC culture of tumor samples where appropriate. Objective 4 Support a comprehensive, prospective interactive database with detailed clinical and pathologic data for patients with CNS tumors receiving care or evaluation at MD Anderson Cancer Center Objective 5 Facilitate inter-SPORE collaborations through sharing of tissue resources

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DO NOT EXCEED THE SPACE PROVIDED. Research into brain cancer depends on the availability of tumor samples obtained from patients. These samples and the DNA, RNA, proteins, and cells derived from them (e.g. GSCs) are the foundation of any translational program. This Core provides the patient samples that are key to understanding and curing brain tumors.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-RPRB-7 (M1))
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University of Texas MD Anderson Cancer Center
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Ji, Haitao; Lee, Jong-Ho; Wang, Yugang et al. (2016) EGFR phosphorylates FAM129B to promote Ras activation. Proc Natl Acad Sci U S A 113:644-9
Hodges, Tiffany R; Ferguson, Sherise D; Heimberger, Amy B (2016) Immunotherapy in glioblastoma: emerging options in precision medicine. CNS Oncol 5:175-86
Zhou, Aidong; Lin, Kangyu; Zhang, Sicong et al. (2016) Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22. Nat Cell Biol 18:954-66
Ohtsuka, Masahisa; Ling, Hui; Ivan, Cristina et al. (2016) H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer. EBioMedicine :
Shah, Maitri Y; Ferrajoli, Alessandra; Sood, Anil K et al. (2016) microRNA Therapeutics in Cancer - An Emerging Concept. EBioMedicine 12:34-42
Lee, J; Jain, R; Khalil, K et al. (2016) Texture Feature Ratios from Relative CBV Maps of Perfusion MRI Are Associated with Patient Survival in Glioblastoma. AJNR Am J Neuroradiol 37:37-43
Gabrusiewicz, Konrad; Rodriguez, Benjamin; Wei, Jun et al. (2016) Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype. JCI Insight 1:
Xue, Jianfei; Zhou, Aidong; Wu, Yamei et al. (2016) miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis. Cancer Res 76:4293-304
Chen, Yaohui; Li, Yu; Xue, Jianfei et al. (2016) Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation. EMBO J 35:668-84
Park, Soon Young; Piao, Yuji; Thomas, Craig et al. (2016) Cdc2-like kinase 2 is a key regulator of the cell cycle via FOXO3a/p27 in glioblastoma. Oncotarget 7:26793-805

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