A major goal of the DF/HCC Gl SPORE is to identify and fund projects that will lead to clinically testable hypotheses aimed at reducing the incidence and mortality rate of Gl cancers or improving the quality of life of patients with Gl cancers. The Developmental Research Program (DRP) supports short-range studies to establish the results needed to facilitate well-validated, hypothesis-driven translational projects. Although the DRP funds established investigators, an important goal is to identify and stimulate interest in Gl cancer research among groups whose current focus may be different but sufficiently related. The Developmental Projects Program is led a highly qualified committee of DF/HCC researchers who participate actively in the selection and ongoing review of pilot projects and who represent laboratory, population and clinical science across the Harvard institutions. The DRP provides the depth and flexibility required to maintain innovation in Gl SPORE activities. During the prior funding cycle, the DF/HCC SPORE supported 18 highly innovative and productive developmental projects that have enabled novel discoveries and 29 successful grant applications to further their ongoing research. The DRP will continue to support novel research in Gl cancer and has the following specific aims: 1. Solicit pilot projects in Gl cancer translational research that have significant potential for reducing the incidence and mortality rate of Gl cancer and/or improving the quality of life of patients with Gl cancers. 2. Foster collaborative efforts among SPORE investigators and with other investigators to encourage the development of new and innovative ideas and approaches. 3. Monitor the progress of the projects and provide critical feedback. 4. Encourage and assist investigators with promising preliminary data developed with support of this Program to apply for extramural peer-reviewed funding. 5. When necessary or possible, promote the most promising projects in the Developmental Research Program to full SPORE research projects.

Public Health Relevance

The DF/HCC Gl SPORE Developmental Research Program seeks to support and nuture new innovative research efforts aimed at reducing the incidence and mortality rate of Gl cancers or improving the quality of life of patients with Gl cancers. To date, the Program has supported 18 novel and productive projects that are making meaningful discoveries in our understanding of Gl cancer biology, prevention, and therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA127003-07
Application #
8933247
Study Section
Special Emphasis Panel (ZCA1-RPRB-M (J1))
Program Officer
Agarwal, Rajeev K
Project Start
2007-04-01
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
7
Fiscal Year
2014
Total Cost
$170,766
Indirect Cost
$60,788
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Russo, Mariangela; Siravegna, Giulia; Blaszkowsky, Lawrence S et al. (2016) Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer. Cancer Discov 6:147-53
Kim, Sun A; Inamura, Kentaro; Yamauchi, Mai et al. (2016) Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis. Br J Cancer 114:199-206
Kugel, Sita; Sebastián, Carlos; Fitamant, Julien et al. (2016) SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b. Cell 165:1401-15
Delaney, Susan K; Hultner, Michael L; Jacob, Howard J et al. (2016) Toward clinical genomics in everyday medicine: perspectives and recommendations. Expert Rev Mol Diagn 16:521-32
Mima, Kosuke; Cao, Yin; Chan, Andrew T et al. (2016) Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location. Clin Transl Gastroenterol 7:e200
Whitley, Melodi Javid; Cardona, Diana M; Lazarides, Alexander L et al. (2016) A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. Sci Transl Med 8:320ra4
Ahronian, Leanne G; Corcoran, Ryan B (2016) Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations. Mol Cell Oncol 3:e1048405
Saha, Supriya K; Zhu, Andrew X; Fuchs, Charles S et al. (2016) Forty-Year Trends in Cholangiocarcinoma Incidence in the U.S.: Intrahepatic Disease on the Rise. Oncologist 21:594-9
Ou, Wen-Bin; Lu, Minmin; Eilers, Grant et al. (2016) Co-targeting of FAK and MDM2 triggers additive anti-proliferative effects in mesothelioma via a coordinated reactivation of p53. Br J Cancer 115:1253-1263
Zeng, Chenjie; Matsuda, Koichi; Jia, Wei-Hua et al. (2016) Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Gastroenterology 150:1633-45

Showing the most recent 10 out of 481 publications